Semaphorin 3A (SEMA3A) was initially identified to play an important role in axonal guidance. Recently, SEMA3A has also been considered as a candidate tumor suppressor, since it is often downregulated in numerous types of cancer, including prostate cancer, breast cancer and glioma. However, the biological role of SEMA3A in ovarian cancer is not clear. In the present study, the expression of SEM...

© Translational Andrology and Urology. All rights reserved. Transl Androl Urol, 2015;4(S1) www.amepc.org/tau maternal age (≥40 years) or any other risk factor for poor ovarian response; (II) a previous poor ovarian response (≤3 oocytes with a conventional stimulation protocol); (III) an abnormal ovarian reserve test (i.e., AFC <5-7 follicles or AMH <0.5-1.1 ng/mL). For these poor responders, th...

BACKGROUND Insulin-like growth factor-1 (IGF-1) is known to play a role in ovarian follicular development augmenting the action of FSH. Low intrafollicular concentrations have been detected in women who respond poorly to gonadotrophins. This study addresses the relationship between serum IGF-1 levels following pituitary desensitization and ovarian response to gonadotrophin stimulation. METHOD...

PURPOSE To discover novel prognostic biomarkers in ovarian serous carcinomas. METHODS A meta-analysis of all single genes probes in the TCGA and HAS ovarian cohorts was performed to identify possible biomarkers using Cox regression as a continuous variable for overall survival. Genes were ranked by p-value using Stouffer's method and selected for statistical significance with a false discover...

Despite the fact that in the last two decades an enormous number of papers on the topic of poor ovarian response have been published in the literature, so far it has been impossible to identify any efficient treatment to improve the ovarian response and the clinical outcome of this group of patients. The incidence of poor ovarian responders among infertile women has been estimated at 9-24% but ...

Age related fertility decline varies considerably among women. Therefore, chronological female age, though informative on pregnancy prospects in assisted reproduction, will often not correctly express a woman's reproductive potential. The value of quantitative ovarian reserve tests prior to IVF/ICSI treatment is still subject of debate. From a series of systematic reviews it has become clear th...