Physico-chemical profiling is a fundamental tool at the early stage of drug discovery in screening drug-like candidates. Complex physico-chemical profiling, including molecular properties such as solubility, ionization, lipophilicity and permeability, has been found to be of predictive power in ADME (absorption, distribution, metabolism, elimination). In the present thesis work, the physico-che...

Egg lecithin is a complex mixture of phosphatides that consists mainly of phosphatidylcholine and phosphatidylethanolamine, combined with various amounts of other substances such as triglycerides and fatty acids [1]. As pharmaceutical excipient lecithin is used in parenteral emulsions, liposomes and mixed micellar solutions. It has been proved, that aqueous dispersions of lecithin (Water-Lecith...

We explore the phase behaviour, solution conformation, and interfacial properties of bottlebrush polymers with side-chains comprised of poly(N-isopropylacrylamide) (PNIPAAM), a thermally responsive polymer that exhibits a lower critical solution temperature (LCST) in water. PNIPAAM bottlebrush polymers with controlled side-chain length and side-chain end-group structure are prepared using a "gr...

diosmin, a vascular-protecting agent, is practically insoluble in water, and its oral absorption is limited by its extremely low dissolution rate. in this study, β-cyclodextrin (βcd) and 2-hydroxypropyl-β-cyclodextrin (hpβcd) were obtained to improve the solubility and dissolution rate of diosmin. phase solubility studies of diosmin with βcd and hpβcd in distilled water were conducted to charac...

Because of the high water solubility in wadsleyite and ringwoodite, the mantle transition zone is possibly a large water reservoir. The potentially high water content of the Earth's mantle transition zone is a key element of several global mantle dynamic models. Nevertheless, to keep the transition zone relatively wet, the tendency for convection to distribute water over the entire mantle has t...

While rapamycin was discovered as a fungicide in 1975, it is now famous for its ability to suppresses mammalian cell aging and to extend lifespan in mice. Rapamycin is an oral immunomodulatory agent approved to prevent rejection in human organ transplantation. It also exerts an antitumor activity as well as an anti-restenosis activity, when used in drugeluting stents. In addition, rapamycin has...

Aceclofenac is a non-steroidal anti-inflammatory drug (NSAID) that exhibits analgesic, antipyretic and anti-inflammatory activities. It is practically insoluble in water. The effect of hydrotropes such as urea and sodium citrate and blends (urea + sodium citrate) on the solubility of aceclofenac was investigated. The enhancement in the solubility of aceclofenac was more than 5 and 25 folds in 3...

BACKGROUND Flubendazole (FLBZ) is a poor water solubility broad-spectrum BZD methylcarbamate anthelmintic compound. Cyclodextrins (CDs) are usually used to increase aqueous solubility of poor hydrosoluble compounds. The comparative in vitro aqueous solubility of FLBZ and other BZD anthelmintics in the presence of hydroxypropyl-β-cyclodextrin (HPβCD) was evaluated in the current work. Additional...

Oral administration of indomethacin has been limited by its poor water solubility. Cyclodextrins have been recognized as potential candidates to overcome the poor solubility of indomethacin through the formation of inclusion complexes. The aim of our study was to compare the dissolution profiles of pure indomethacin and its mixtures with α- and γ-cyclodextrins The inclusion complexes of indomet...