We present the case of a 36 year old woman with systemic lupus erythematosus with hematological, skin and joint affection, with an onset 21 years prior. The immunologic study showed positive ANA (titer 1:1,000, homogeneous pattern), anti-DNA, anti-ENA and anti-Ro (SSA). She presented multiple hard subcutaneous nodules on the trunk and extremities since 10 years prior, which tended to conglomera...

Childhood abuse increases adult risk for morbidity and mortality. Less clear is how this "toxic" stress becomes embedded to influence health decades later, and whether protective factors guard against these effects. Early biological embedding is hypothesized to occur through programming of the neural circuitry that influences physiological response patterns to subsequent stress, causing wear an...

In recent years, there has been much focus on the apparent heterogeneity of schizophrenic symptoms. By contrast, this article proposes a unifying account emphasizing basic abnormalities of consciousness that underlie and also antecede a disparate assortment of signs and symptoms. Schizophrenia, we argue, is fundamentally a self-disorder or ipseity disturbance (ipse is Latin for "self" or "itsel...

Currently, the most prominent way of subtyping schizophrenic symptoms is the distinction between the “positive” and “negative” syndromes (often supplemented by a third group of “disorganization” symptoms). This article offers a theoretical and phenomenological critique of this distinction, focusing on the subjective experience of the so-called “negative symptoms,” and utilizing the autobiograph...

INTRODUCTION Cutaneous melanoma (CM) is an aggressive skin cancer entity, causing most skin cancer-related deaths. Autoimmune disorders have been described as potential paraneoplastic complications. The purpose of this study was to elucidate the possibility of a combinatory paraneoplastic affection of the retina and cochlea in patients with CM. METHODS Sera samples from CM patients were used ...

BACKGROUND Long-standing theory suggests that quality of the mother's (or primary caregiver's) interaction with a child is a key determinant of the child's subsequent resilience or vulnerability and has implications for health in adulthood. However, there is a dearth of longitudinal data with both objective assessments of nurturing behaviour during infancy and sustained follow-up ascertaining t...

Company, Limited. 1903. The author describes his work as a clinical guide to the diagnosis and treatment of diseases of women, and states in the preface that he has endeavoured to present these affections in the way in which they appear in practice. As a clinical guide the work is most reliable, and the manner in which the author presents his subject is thoroughly practical. We do not feel sure...

This study examined the associations between relationship qualities, sexual behaviors, and relationship length in 61 adolescent couples (aged 16-20). For both male and female partners, positive relationship qualities were associated with physical expressions of affection. Perceptions of higher levels of conflict and frustration were associated with more frequent sexual intercourse. Factor analy...