نتایج جستجو برای: potassium channelopathy
تعداد نتایج: 77926 فیلتر نتایج به سال:
A young man suffered cardiac arrests with polymorphic ventricular tachycardia (PVT) and ventricular fibrillation (VF) triggered by ventricular premature contractions (PVCs). The arrhythmia was resistant to anti-arrhythmics, so after ICD implantation he underwent successful ablation of the triggering VE beat, which was pace-mapped to the left posterior hemi-fascicle. We review the evidence for t...
I on channels are protein valves that control an enormous range of biological function. Atomic-scale properties of channel proteins control macroscopic flows across otherwise insulating membranes of cells and subcellular compartments, and so the study of channels is a study in atomic biology. Ion channels are intrinsically multiscale devices that allow the amino acid side chains of a protein to...
Abstract Cardiac ion channelopathies encompass a set of inherited or acquired conditions that are due to dysfunction in channels their associated proteins, typically the presence structurally normal hearts. They with development ventricular arrhythmias and sudden cardiac death. The aim this review is provide historical perspective recent advances research channelopathies, Brugada syndrome, long...
Kv7.x (KCNQ) voltage-gated potassium channels form the cardiac and auditory I(Ks) current and the neuronal M-current. The five Kv7 subtypes have distinct assembly preferences encoded by a C-terminal cytoplasmic assembly domain, the A-domain Tail. Here, we present the high-resolution structure of the Kv7.4 A-domain Tail together with biochemical experiments that show that the domain is a self-as...
Cerveau et de L’Œil, Groupe Hospitalier Lariboisière – Fernand Widal, Paris, France ; 5 INSERM UMR_S 740, Université Paris Diderot, Sorbonne Paris Cité, Paris 6 Service de Neurologie, CHU de Limoges, Hôpital Dupuytren, Limoges, France; 7 Service de Cardiologie, CHU de Limoges, Hôpital Dupuytren, Limoges, France; 8 Unité Mixte de Recherche en Santé (UMR_S956), Université Pierre & Marie Curie (UP...
Episodic ataxia type 1 is a neuronal channelopathy caused by mutations in the KCNA1 gene encoding the fast K(+) channel subunit K(v)1.1. Episodic ataxia type 1 presents with brief episodes of cerebellar dysfunction and persistent neuromyotonia and is associated with an increased incidence of epilepsy. In myelinated peripheral nerve, K(v)1.1 is highly expressed in the juxtaparanodal axon, where ...
Megalencephalic leukoencephalopathy with subcortical cysts (MLCs) disease is a rare inherited, autosomal recessive form of childhood-onset spongiform leukodystrophy characterized by macrocephaly, deterioration of motor functions, epileptic seizures and mental decline. Brain edema, subcortical fluid cysts, myelin and astrocyte vacuolation are the histopathological hallmarks of MLC. Mutations in ...
نمودار تعداد نتایج جستجو در هر سال
با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید