BACKGROUND AND AIMS Obesity compromises adipocyte physiology. PPARs are essential to adipocyte plasticity, but its isolated role in the browning phenomenon is not clear. This study aimed to examine whether activation of PPAR-α or PPAR-β/δ could induce beige cell depots in the subcutaneous white adipose tissue of diet-induced obese mice. MATERIAL AND METHODS Sixty animals were randomly assigne...

PPAR and C/EBP are critical transcription factors in adipogenesis, but the precise role of these proteins has been difficult to ascertain because they positively regulate each other’s expression. Questions remain about whether these factors operate independently in separate, parallel pathways of differentiation, or whether a single pathway exists. PPAR can promote adipogenesis in C/EBP -deficie...

The previous results suggest that peroxisome proliferator-activated receptor-alpha (PPAR)-alpha, an intracellular transcription factor activated by fatty acids, plays a role in control of inflammation. There is persuasive epidemiological and experimental evidence that dietary polyphenols have anti-inflammatory activity. In this regard, it has been demonstrated that verbascoside (VB) functions a...

Peroxisome proliferator-activated receptor (PPAR ) is a ligand-activated transcription factor belonging to the nuclear hormone receptor superfamily. PPAR is expressed by macrophages, endothelial cells, and vascular smooth muscle cells. It regulates gene expression of key proteins involved in lipid metabolism, vascular inflammation, and proliferation contributing to atherogenesis and postangiopl...

Peroxisome proliferator-activated receptors (PPARs) belong to the nuclear family of ligand activated transcriptional factors and comprise three different isoforms, PPAR-α, PPAR-β/δ, and PPAR-γ. The main role of PPARs is to regulate the expression of genes involved in lipid and glucose metabolism. Several studies have demonstrated that PPAR agonists improve dyslipidemia and glucose control in an...

Thiazodinedione (TZD) agonists of the peroxisome proliferator activated receptor gamma (PPAR ) exert metabolic effects in glial cells. In primary astrocytes, TZDs are cytoprotective and have anti-inflammatory actions; in contrast, in glioma cells TZDs are cytotoxic. Although PPAR is considered their primary target, TZDs including pioglitazone and troglitazone also bind to a mitochondrial protei...

Neutrophils (polymorphonuclear leukocytes [PMNs]) are critical to the immune response, including clearance of infectious pathogens. Sepsis is associated with impaired PMN function, including chemotaxis. PMNs express peroxisome proliferator-activated receptor-gamma (PPAR-gamma), a ligand-activated nuclear transcription factor involved in immune and inflammatory regulation. The role of PPAR-gamma...

The peroxisome proliferator–activated receptor a (PPAR a ) is a nuclear receptor implicated in the control of cellular lipid utilization. To test the hypothesis that PPAR a is activated as a component of the cellular lipid homeostatic response, the expression of PPAR a target genes was characterized in response to a perturbation in cellular lipid oxidative flux caused by pharmacologic inhibitio...

Peroxisome proliferator-activated receptor delta (PPAR-delta), one of three PPAR subtypes, is a lipid-sensing nuclear receptor that has been implicated in multiple processes, including inflammation and cancer. To directly establish the role of PPAR-delta in colon cancer development and progression, we selected high-affinity RNA aptamers and expressed them in several colon cancer cell lines. Nuc...