BACKGROUND Intrauterine infection may play a role in preterm delivery due to spontaneous preterm labor (PTL) and preterm prolonged rupture of membranes (PPROM). Because bacteria previously associated with preterm delivery are often difficult to culture, a molecular biology approach was used to identify bacterial DNA in placenta and fetal membranes. METHODOLOGY/PRINCIPAL FINDINGS We used broad...

OBJECTIVE To evaluate maternal serum C-reactive protein (CRP) concentrations in pregnancies complicated by preterm prelabor rupture of membranes (PPROM) in relation to the presence of microbial invasion of the amniotic cavity (MIAC) and/or intra-amniotic inflammation (IAI). METHODS Two hundred and eighty-seven women with singleton pregnancies complicated by PPROM between 2014 and 2016 were in...

Amniotic band syndrome (ABS) is a rare congenital condition, occurring as an outcome of entanglement fetal parts with amniotic bands during intrauterine life resulting in anatomical abnormalities. ABS should be considered every newborn malformations. In this report, case preterm female baby delivered to diagnosed (Preterm pre-labour rupture membranes) PPROM mother, abnormalities the extremities...

Early events leading to intrauterine infection remain poorly defined, but may hold the key to preventing preterm delivery. To determine molecular pathways within fetal membranes (chorioamnion) associated with early choriodecidual infection that may progress to preterm premature rupture of membranes (PPROM), we examined the effects of a Group B Streptococcus (GBS) choriodecidual infection on cho...

BACKGROUND Preterm deliveries complicate 11% of all births within the United States. In the urban inner city population, this figure approaches approximately 18%. In one quarter to one third of these deliveries, preterm premature rupture of the membranes (PPROM) has been a causative factor. OBJECTIVE The purpose of this study was to evaluate outcomes of pregnancies complicated by preterm prem...

Objectives: To evaluate the usefulness of serum C-reactive protein (CRP) in women with preterm prelabour rupture of membranes (PPROM) in the prediction of funisitis and early-onset neonatal sepsis (EONS), to determine a CRP cutoff value for their prediction, and to identify other significant risk factors associated with funisitis and EONS. Methods: This was a retrospective study conducted in a ...

Classic IL-6 signaling is conditioned by the transmembrane receptor (IL-6R) and homodimerization of gp130. During trans-signaling, IL-6 binds to soluble IL-6R (sIL-6R), enabling activation of cells expressing solely gp130. Soluble gp130 (sgp130) selectively inhibits IL-6 trans-signaling. To characterize amniotic fluid (AF) IL-6 trans-signaling molecules (IL-6, sIL-6R, sgp130) in normal gestatio...

Preterm premature rupture of membranes (PPROM) occurs in 3 percent of all pregnancies and is responsible for, or associated with, approximately one-third of preterm births causing significant perinatal morbidity and fetal death. Preterm infants are very vulnerable to respiratory distress syndrome (RDS), intraventricular hemorrhage (IVH), periventricular leucomalacia (PVL), other neurological se...

BACKGROUND To report the outcomes of women admitted following preterm pre-labour rupture of membranes (pPROM) and to determine whether the location of care (hospital vs outpatient) influences maternal and perinatal outcomes. METHODS A retrospective cohort study was performed using routinely collected de-identified data of 144 women (between June 2007 and June 2011) who presented to the Mater ...