Recombinant adeno-associated viral (AAV) vectors are known to safely and efficiently transduce the retina. Among the various AAV serotypes available, AAV2/5 and 2/8 are the most effective for gene transfer to photoreceptors (PR), which are the most relevant targets for gene therapy of inherited retinal degenerations. However, the search for novel AAV serotypes with improved PR transduction is o...

INTRODUCTION Patients who are surgically treated for an acute hip fracture in Denmark commence early in-hospital physical rehabilitation (PR) with more than 95% of patients referred to further PR following discharge. However, the specifics of the PR services after discharge are unknown. Thus, the aim of the present paper was to describe the specifics of PR provided to patients following dischar...

Many children are at risk of not achieving their full potential for development. Epidemiological studies have the advantage of being able to identify a number of associated factors potentially amenable to intervention. Our purpose was to identify risk factors for suspected developmental delay (SDD) at age 2 years among all children born in the city of Pelotas, Brazil, in 2004. This study was pa...

OBJECTIVES To examine the sex-specific factors associated with being unaware of one's hepatitis B virus surface antigen (HBsAg) seropositivity status in a large, HBsAg-positive population of Koreans. METHODS In total, 1197 subjects aged 19 years or older who were HBsAg-positive according to data from the 2007-2012 Korea National Health and Nutrition Examination Survey were included. Subjects ...

We measured the elastic constants (C11 − C12)/2 and C44 of non-Kramers system Y0.63Pr0.37Ir2Zn20 (Pr-37% system) by means ultrasound to check how single-site quadrupolar Kondo effect is modified increasing Pr concentration. The Curie-like softening present Pr-37% on cooling from 5 1 K can be reproduced a multipolar susceptibility calculation based Γ3 doublet crystalline-electric-field ground st...

Treatment of toluene solutions of the silylenes Si(SAr(Me6))2 (Ar(Me6) = C6H3-2,6(C6H2-2,4,6-Me3)2, 1) or Si(SAr(Pr(i)4))2 (Ar(Pr(i)4) = C6H3-2,6(C6H3-2,6-Pr(i)2)2, 2) with excess ethylene gas affords the siliranes (Ar(Me6)S)2SiCH2CH2 (3) or (Ar(Pr(i)4)S)2SiCH2CH2 (4). Silirane 4 evolves ethylene spontaneously at room temperature in toluene solution. A Van't Hoff analysis by variable-temperatur...

BACKGROUND Herpes simplex virus type 2 (HSV-2) is the leading cause of genital ulcer disease in developing countries, including Brazil, and is especially prevalent among men who have sex with men (MSM). HSV-2 infection represents a risk factor for the acquisition and transmission of other sexually transmitted diseases. The goal of the present cross-sectional study was to estimate HSV-2 seroprev...

Photosynthetic carbon metabolism of isolated spinach mesophyll cells was characterized under conditions favoring photorespiratory (PR; 0.04% CO(2) and 20% O(2)) and nonphotorespiratory (NPR; 0.2% CO(2) and 2% O(2)) metabolism, as well as intermediate conditions. Comparisons were made between the metabolic effects of extracellularly supplied NH(4) (+) and intracellular NH(4) (+), produced primar...

OBJECTIVE To compare the clinicopathologic features and survival in the four breast cancer subtypes defined by immunohistochemistry (IHC) expression of estrogen receptor (ER) or progesterone receptor (PR) and human epidermal growth factor receptor 2 (Her2): ER/PR+, Her2+; ER/PR+, Her2-; ER/PR-, Her2+; and ER/PR-, Her2-. METHODS A 7-year retrospective study of 1134 invasive breast cancer subje...