نتایج جستجو برای: pr 5
تعداد نتایج: 1240809 فیلتر نتایج به سال:
Human progesterone receptors (PR) exist as two functionally distinct isoforms, PR-A and PR-B. The proteins are identical except for an additional 164 residues located at the N terminus of PR-B. To determine the mechanisms responsible for isoform-specific functional differences, we present here a thermodynamic dissection of PR-A-promoter interactions and compare the results to our previous work ...
BY NATALIYA V. MAKSIMCHUK1, OLGA V. ZALOMAEVA1, IGOR Y. SKOBELEV1, KONSTANTIN A. KOVALENKO2,3, VLADIMIR P. FEDIN2,3 AND OXANA A. KHOLDEEVA1,* 1Boreskov Institute of Catalysis, pr. Lavrentieva 5, Novosibirsk 630090, Russia 2Nikolaev Institute of Inorganic Chemistry, pr. Lavrentieva 3, Novosibirsk 630090, Russia 3Department of Inorganic Chemistry, Novosibirsk State University, Pirogova str. 2, No...
BACKGROUND The recent literature indicates that a high vegetable intake and not a high fruit intake could be associated with decreased steroid hormone receptor-negative breast cancer risk. OBJECTIVE This study aimed to investigate the association between vegetable and fruit intake and steroid hormone receptor-defined breast cancer risk. DESIGN A total of 335,054 female participants in the E...
CONTEXT Asoprisnil, a selective progesterone (P4) receptor (PR) modulator (SPRM) with mixed P4 agonist/antagonist activities, reduces uterine leiomyoma volume in a dose-dependent manner in the presence of follicular phase estrogen concentrations. The evidence from clinical studies suggests that asoprisnil may directly target the uterine leiomyomata. OBJECTIVE AND METHODS The present study eva...
BACKGROUND The PR interval on the ECG reflects atrial depolarization and atrioventricular nodal delay which can be partially differentiated by P wave duration and PR segment, respectively. Genome-wide association studies have identified several genetic loci for PR interval, but it remains to be determined whether this is driven by P wave duration, PR segment, or both. METHODS AND RESULTS We r...
BACKGROUND To examine whether pregnancy rate (PR) of intrauterine insemination (IUI) is related to certain demographic factors, such as age and body mass index (BMI), along with number of IUI cycles performed, a set of infertile Saudi women. MATERIALS AND METHODS During this prospective study (a 24-month period), 301 Saudi women with infertility underwent IUI in our infertility clinic. We inv...
Hormonal factors have a profound influence on the development, treatment, and outcome of breast cancer. The absence of steroid hormone receptors is highly correlated with resistance to antihormonal treatments. Work in cultured human breast cancer cell lines has shown that the absence of estrogen receptor (ER) gene expression in ERcells is associated with extensive methylation of the ER gene 5’ ...
Polish Red (PR) is the native Polish cattle breed included in the FAO National Rare Livestock Breeds Preservation Programme. The breed is characterized by high vitality and fertility, calving ease, resistance to diseases, and low requirements for feed. Milk yield is low, but fat and protein content of milk are high. The frequencies of alleles of commonly studied loci as well as the presence of ...
The main objective of this paper is to investigate the distribution Andrews-Garvan-Dyson cranks partitions. Let M(m,n) denote number partitions n with crank m, we show that sequence {M(m,n)}|m|≤n−1 unimodal for n≥44. It turns out unimodality related monotonicity properties two partition functions pr(n) and ppr(n). parts taken from {2,3,…,r} let ppr(n) pairs (α,β) partitions, where α a counted b...
Pityriasis rosea (PR) is an acute, self-limiting papulosquamous exanthem. A number of atypical variants of PR, regarding morphology and distribution of the lesions or severity of the symptoms, may be observed. Herein, we present the first case of atypical PR with hypopigmented lesions and a target-shape herald patch.
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