OBJECTIVES Individuals at risk for Huntington disease face difficult decisions regarding their reproductive options. Most do not wish to pass on the gene for Huntington disease to their children, but may not be prepared themselves to undergo presymptomatic testing and learn their genetic status. For these reasons, many at-risk individuals with a family history of HD would choose a method of gen...

Cystic fibrosis (CF) is the most common genetic disease among Caucasians. Duchenne muscular dystrophy (DMD) is one of the most common X-linked genetic disorders. The CF and DMD genes were discovered a few years ago, which provided the possibility for prenatal diagnosis and preimplantation diagnosis of CF and DMD by using specific DNA analysis. In this article, CF, DMD, the process of the identi...

Sir, We read with great interest a recent systematic review by Lee et al. published inyour journal evaluating the clinical effectivenessofpreimplantation genetic diagnosis for aneuploidy in all 24 chromosomes (PGD-A) (Lee et al., 2015). The authors conclude that, for the time being, the role for PGD-A remains uncertain regarding its clinicaland costeffectiveness. In our opinion, a number of obs...

Synopsis – Developments in in vitro fertilization techniques and recombinant DNA technology are improving the technical feasibility of genetically manipulating human embryos. The combination of these technologies allows a new form of eugenic selection to be practiced and some IVF practitioners and researchers are advocating that genetic disorders can be eradicated from future generations in the...

A previous study comparing the performance of different platforms for DNA microarray found that the oligonucleotide (oligo) microarray platform containing 385K isothermal probes had the best performance when evaluating dosage sensitivity, precision, specificity, sensitivity and copy number variations border definition. Although oligo microarray platform has been used in some research fields and...