provided the original work is properly cited. CC Treacher Collins syndrome (Mandibulofacial Dysostosis, TCS) is characterized by antimongoloid slanting of the palpebral fissures, coloboma of the lower lid, micrognathia and hypoplasia of the zygomatic arches, and microtia. TCS appears to be inherited in an autosomal dominant fashion or occurs sporadically, and is a congenital malformation of the...

Sir,—Observations of leucocytosis following anaesthesia and surgery are certainly not new. Current interest is, for the most part, centred around possible depression of cellular immune response by the various anaesthetic agents on the cancer patient treated by surgery. The high incidence of apparently "anaphylactoid" or hypersensitivity-type adverse responses to the newer i.v. anaesthetic agent...

Proteinase inhibitor genes are expressed in solanaceous and leguminous plants following wounding of the foliage by mechanical methods. Previous studies have shown that a cloned proteinase inhibitor I1-chloramphenicol acetyl transferase (pin2-CAT) chimeric gene is regulated in a wound-inducible manner in transgenic plants. In this study, we analyzed transgenic plant tissues for expression of the...

Differentiation of murine erythroleukemia (MEL) cells induced by hexamethyhene bisacetamide (HMBA) and DMSO was inhibited by several structurally unrelated nitric oxide (NO)-reheasing agents and two membranepermeable cGMP analogues. Since the effect of the NOreleasing agents was augmented by a cGMP phosphodiesterase inhibitor, at least some of their effect appeared to be mediated by activation ...

EDITOR: The ideal anaesthetic for day-surgery procedures should give quick recovery without pain, nausea or vomiting and ensure a rapid return to preoperative mental state with rapid discharge and patient satisfaction. Ketamine was introduced into clinical practice nearly 40 yr ago but its use has declined. It nevertheless remains in regular use in certain surgical disciplines, e.g. paediatrics...

Fetal head descent can be expressed as fetal station and engagement. Station is traditionally based on clinical vaginal examination of the distal part skull related to level ischial spines. Engagement a transabdominal proximal above pelvic inlet. Clinical examinations are subjective, objective measurements warranted. Ultrasound feasible diagnostic tool in labor, lie, station, position, presenta...

Combined modality therapy for lung cancer was first demonstrated to be successful in limited-stage small cell lung cancer. Concurrent administration of chemotherapy with chest and elective brain irradiation appears to produce the best results, with cisplatin/etoposide as the core chemotherapy. Using such programs, 2-year survival in the 40% range and 5-year survivals in excess of 20% may be exp...