Medium-chain acyl-coenzyme A dehydrogenase (MCAD) deficiency is the most common disorder of mitochondrial fatty acid oxidation. We report a term male infant who presented at 3 days of age with hypoglycemia, compensated metabolic acidosis, hypocalcemia, and prolonged QTc interval. Pregnancy was complicated by maternal premature atrial contractions and premature ventricular contractions. Prolonga...

Here the histopathology findings of placental infarction associated with late preterm birth are reported. The subject was a male neonate delivered at 34 weeks and 5 days of gestation with a birth weight of ∼2500 g. His mother had been diagnosed with a threatened premature birth at 27 weeks of pregnancy. The size and weight of the placenta was considered appropriate for gestational age. On the c...

A case is presented of a serious, potentially life-threatening intravenous acetaminophen overdose in a 3month-old (40 weeks’ post menstrual age), 2.3 kg baby girl. The neonate was scheduled for urgent laser therapy for retinopathy of prematurity. Instead of an intended intravenous Hartmann’s solution bolus of 10 ml·kg, the neonate received a 17 ml bolus of correctly labelled intravenous 1% acet...

Manganese (Mn) is an essential trace metal found in all tissues, and it is required for normal amino acid, lipid, protein, and carbohydrate metabolism. While Mn deficiency is extremely rare in humans, toxicity due to overexposure of Mn is more prevalent. The brain appears to be especially vulnerable. Mn neurotoxicity is most commonly associated with occupational exposure to aerosols or dusts th...

This Clinical Guideline has been developed to guide clinical practice based on the authors’ assessment of current published evidence on glycemic control in the neonate (within the first month of life) receiving parenteral nutrition (PN). The neonate receiving PN is worthy of special consideration with respect to glucose control, as this population carries an elevated risk of hyperand hypoglycem...

aintaining acid base balance presents a considerable challenge to the growing neonate. The infant ust ingest protein for growth and development. The metabolism of sulfur containing amino acids eads to the production of protons that must be secreted by the kidney. In addition, the formation of ydroxyapatite for the mineralization of growing bone also leads to acid production. Thus, the rowing in...

Meningitis in newborn continue to be major cause of morbidity and mortality, particular premature infant.
 Incidence is 0.2 0.4\1000 live birth higher The sign symptoms meningitis are not specific diagnosis depends on laboratory investigation.
 Objective: To find the value CRP camper with WBC count cases proved based lumber puncture finding.
 Design: Retrospective study, cross se...

Landmark studies have established taxanes in the treatment of patients with breast cancer; however, recommendations regarding their administration during pregnancy are controversial. The present systematic review aims to synthesize all available data that stem exclusively from breast cancer case series to evaluate the efficacy and safety of taxanes during pregnancy. Overall, 16 studies (50 preg...