Fifty patients with premature gonadal failure were subdivided into primary and secondary failure groups. Karyotyping in the primary and ovarian histological examination in the secondary group are preferred diagnostic procedures. Several rare clinical syndromes are mentioned. Possible aetiological factors are identified, and a plea is made for the accurate diagnosis of this condition. Diagnostic...

BACKGROUND Approximately 10% of women suffer from premature ovarian senescence (POS), ca. 9% as occult primary ovarian insufficiency (OPOI, also called premature ovarian aging, POA) and ca. 1% as primary ovarian insufficiency (POI, also called premature ovarian failure, POF). In a large majority of cases POS is currently only diagnosed at advanced clinical stages when women present with clinica...

BACKGROUND Premature ovarian failure (POF) is a common condition; its incidence is estimated to be as great as 1 in 100 by the age of 40 years. Physiologic replacement of ovarian steroid hormones seems rational until the age of normal menopause. Temporary return of ovarian function and pregnancy may occur rarely in women with POF. We report a case of POF who conceived during hormone replacement...

background and objective: it is well known that menstrual period and ovarian function are affected by chemotherapy. although breast cancer is the most common cause of chemotherapy in women and ovarian hormones have very important direct and indirect effects on overall survival, disease-free survival, and life quality of patients, but few studies have addressed the frequency and related factors ...