Hepatocellular carcinoma (HCC) is a major cause of cancer-related deaths worldwide. MicroRNA-34 (miR-34) gene plays a key role in altering the apoptotic cycle and pathways of downstream cells, and therefore influences carcinogenesis. In this case-control study, we assessed the role of the pri-miR-34b/c rs4938723 polymorphism in HCC risk. The pri-miR-34b/c polymorphic genotype was determined in ...

Synthetic analogs of vitamin D for potential use in differentiation therapy should selectively regulate genes necessary for differentiation without inducing any perturbations in calcium homeostasis. PRI-1906, an analog of vitamin D2, and PRI-2191, an analog of vitamin D3 bind nuclear vitamin D receptor (nVDR) with substantially lower affinity than 1,25-dihydroxyvitamin D3 (1,25-D3), but have hi...

From a simple idea to unite pension funds in their quest for responsible investment at its launch in April 2006, the United Nations supported Principles for Responsible Investment (PRI) have grown in just one decade into an initiative with more than 1,500 fee paying signatories. These signatories consist of asset owners (e.g. pension funds, charities), the asset managers that serve them and ser...

Multiple pulse repetition interval (multi-PRI) transmission is part of an adaptive signal transmission and processing algorithm being developed to aggressively combat range–velocity ambiguity in weather radars. In the past, operational use of multi-PRI pulse trains has been hampered due to the difficulty in clutter filtering. This paper presents finite impulse response clutter filter designs fo...

PURPOSE The decline in U.S. adolescent fertility has accelerated since 2007. Modeling fertility change using behavioral data can inform adolescent pregnancy prevention efforts. METHODS We used data on sexual activity and contraceptive use from National Surveys of Family Growth for young women 15-19 years of age, and contraceptive failure rates, to estimate a Pregnancy Risk Index (PRI) for the...

In this work, we present the Poroelastic Relaxation Indentation (PRI) testing approach for quantifying the mechanical and transport properties of thin layers of poly(ethylene glycol) hydrogels with thicknesses on the order of 200 mm. Specifically, PRI characterizes poroelastic relaxation in hydrogels by indenting the material at fixed depth and measuring the contact area-dependent load relaxati...

Root mat of cucumbers and tomatoes has previously been shown to be caused by Agrobacterium radiobacter strains harboring a root-inducing Ri plasmid (pRi). Nine other pRi-harboring alpha-Proteobacteria have subsequently been isolated from root mat-infected crops. Fatty acid profiling and partial 16S rRNA sequence analysis identified three of these strains as being in the genus Ochrobactrum, five...

MicroRNAs originate from primary transcripts containing hairpin structures. The levels of mature miR156 influence the leaf number prior to flowering in the life cycle of plants. To understand the molecular mechanism of biogenesis of primary miR156a (pri-miR156a) to mature miR156, a base-pair opening dynamics study was performed using model RNAs mimicking the cleavage site of wild type and B5 bu...

An ESM sensor composed of either a single channel or multi channel superhetrodyne receiver followed by Digital receiver and ELINT processor to identify radar emitters in a particular frequency band of interest. In real life, such systems may encounter with a continuous stream of pulses accompanied by many imperfections, and it should work on real-time basis. In order to handle such circumstance...

The aim of the present study was to investigate DNA damage in peripheral blood lymphocytes of breast cancer (BC) patients before and after administration of chemotherapy. We analyzed the frequency of sister chromatid exchange (SCE), occurrence of micronuclei (MN), and lymphocyte proliferation rate index (PRI) as cytogenetic markers in 28 female BC patients before and after chemotherapy, and in ...