anatomy: middle cranial fossa mainly floored by sphenoidal bone and located post. to innominate bone or lesser wing and ant. to temporal bone. main foramens are located in deep part, bilateral to sellae are orbital fissures, optic canals, foramen rotundom, ovale and spinosum, foramen lacerum also meckle cave or trigeminal impression and carotid canal. this fossa is like a butterfly in shape. le...

Denosumab, a human monoclonal antibody that inhibits bone resorption by binding on the receptor activator of the nuclear factor kappa-β ligand, has recently emerged as an additional option in the treatment of musculoskeletal osteolytic tumors. This article focuses on the recent literature regarding the effectiveness of denosumab in the management of giant cell tumor, multiple myeloma, aneurysma...

Bone tumors are fortunately rare, but small cell tumors of bone are a relatively common subset of these lesions. They comprise of a diverse group of primary and metastatic neoplasms in both children and adults. The most common small cell tumors of bone include Ewing sarcoma/primitive neuroectodermal tumor, small cell osteosarcoma, multiple myeloma, lymphoma, leukemia, neuroblastoma, rhabdomyosa...

Veterinary medicine is most often a mysterious world for the human doctors. However, animals are important for human medicine thanks to the numerous biological similarities. Primary bone tumors are not uncommon in veterinary medicine and especially in small domestic animals as dogs and cats. As in human medicine, osteosarcoma is the most common one and especially in the long bones extremities. ...

Bone metastasis remains the most frequent and deadliest complication of prostate cancer (PCa). Mechanisms leading to homing tumor cells bone remain poorly characterized. Role chemokines in providing navigational cues migrating bearing specific receptors is well established. an adipocyte-rich organ since 50 70% adult marrow (BM) volume comprise adipocytes (BM-Ads), which are likely produce withi...

Primary neoplasms of the patella account for less than 1% of all primary bone tumors of the lower extremity, the most frequent of them being the giant cell tumor of bone, the chondroblastoma, and the aneurysmal bone cyst. Herein, we report the case of a 29-year-old woman with an active giant cell tumor of the patella (GCTP) with its clinical and radiological features and a brief review of the l...

Background: Bone marrow is the site of many malignant disorders and it is one of the common places for solid tumors to metastasize. Examination of the bone marrow aspirate and biopsy is a routine procedure performed for assessment of various conditions such as cytopenias, hematologic neoplasms, nonmalignant disorders and metastatic neoplasms. Methods: The patients were referred to the Hema...

Accurate diagnosis of primary bone tumors requires evaluation of clinical, radiologic, and pathologic features. Thus, communication among the orthopedic surgeon, the radiologist, and the pathologist is necessary to avoid serious diagnostic errors and subsequent therapeutic mismanagement. The following clinical parameters provide essential diagnostic information and should be part of every diagn...

Background: The fundamental principles of internal targeted alpha therapy for cancer were established many decades ago.The high linear energy transfer (LET) of alpha radiation to the targeted cancer cellscauses double strand breaks in DNA. At the same time, the short range radiation spares adjacent normal tissues. This targeted approach complements conventional external beam radiotherapy and ch...

Participant in the process of normal bone remodeling is vitamin D, which, addition, has antiinflammatory (anti-cytokine), anti-proliferative and anti-tumor effects. Objective study to assess level 25-hydroxyvitamin D3 concentration blood serum before start treatment patients with benign, primary malignant metastatic tumors, taking into account polymorbidity. Materials methods. The following wer...