The anticonvulsant properties of the ss-adrenoceptor antagonist propranolol and its two enantiomers were examined in various screening tests in order to characterize the anticonvulsant profile as well as the possible molecular mechanism of action. These compounds dose-dependently raised the threshold for tonic electroshock seizures in mice and were effective in the traditional maximal electrosh...

objective the lennox-gastaut syndrome (lgs), one of the most difficult epilepsy syndromes to treat, is characterized by a triad of intractable seizures of various types, a slow (< 2.5-hertz) spike-wave pattern in eeg and mental retardation. the aim of this study was to evaluate the efficacy and safety of lamotrigine as add-on therapy in intractable epilepsy of children with lgs. materials & met...

Case presentation: 17-year-old female patient, single child of non-consanguineous healthy parents. The pregnancy and delivery were uneventful. She presented a normal psychomotor development until 4 months age, when she started with epileptic seizures evolved central hypotonia, appendicular hypertonia, dystonia. After, autistic features, stereotypies, lack response to pain, self-harm did not dev...

Seizure control using deep brain stimulation (DBS) provides an alternative therapy to patients with intractable and drug resistant epilepsy. This paper presents novel DBS stimulus protocols to disrupt seizures. Two protocols are presented: open-loop stimulation and a closed-loop feedback system utilizing measured firing rates to adjust stimulus frequency. Stimulation suppression is demonstrated...

objective: regarding the anticonvulsant effects of satureja hortensis (s. hortensis) in avicenna’s book: canon of medicine; the present study was undertaken to evaluate the anti- eplileptic effects of s. hortensis aqueous and ethanolic aerial part extracts. furthermore, the mechanisms of their anticonvulsant activities were also evaluated. materials and methods: seizure was induced by pentylent...

Background: Seizure is one of the most severe side effects tramadol abuse that can be irreversible. Objectives: This study aimed to investigate frequency abuse-associated seizure and electroencephalogram findings in patients with seizures. Methods: cross-sectional was conducted on generalized tonic-clonic seizures caused by abuse. After history examination systemic neurologic evaluation, abnorm...

Serum phenytoin concentrations were monitored prospectively in 26 patients with previously untreated partial epilepsy, during monotherapy with phenytoin. Only six remained entirely seizure-free, although only four experienced further tonic-clonic seizures. There was no correlation between serum phenytoin concentrations and freedom from partial seizures in those patients in whom such seizures re...