Since the State Agricultural School in Wageningen opened its doors in 1876, the Netherlands has had a school exclusively dedicated to researching, teaching, and propagating agricultural knowledge deemed important to the Dutch nation. Even though for most of its history the school has remained separate and inferior to Dutch academia – graduates of the school receive the telling title ‘agricultur...

A TMSBr/InBr3-promoted Prins cyclization/homobromination reaction of dienyl alcohol with aldehyde has been developed to construct a unique cis-E THP shown as the A ring in (-)-exiguolide and the B ring in bryostatins.

1. Morana RTD d.o.o., Oslica 1b, 1295, Ivančna Gorica, Slovenia 2. University of Ljubljana, Faculty of Chemistry and Chemical Technology, Ljubljana, Aškerčeva 5, 1000 Ljubljana, Slovenia 3. University College London, Centre for Sustainable Heritage, The Bartlett School of Graduate Studies, Gower Street (Torrington Place site), London WC1E 6BT, UK 4. Nationaal Archief, The Hague, Prins Willem Al...

5. Mandell DL, Wald ER, Michaels MG, Dohar JE. Management of nontuberculous mycobacterial cervical lymphadenitis. Arch Otolaryngol Head Neck Surg 2003; 129:341–4. 6. Gerrits JA, Wolfs TF, Geelen SP. Three toddlers with a swelling in the neck [in Dutch]. Ned Tijdschr Geneeskd 2003; 147:225–9. 7. Lindeboom JA, Kuijper EJ, Bruijnesteijn van Coppenraet ES, R. Lindeboom, Prins JM. Surgical excision ...

Novel synergistic effects between Lewis and Brønsted acids in Prins cyclization are reported. Non-reactive Lewis acids and non-reactive Brønsted acids, which failed to perform Prins cyclization when used alone, have shown remarkable synergistic effects when used in combination to perform the reaction successfully.

A domino reaction has been developed for the synthesis of oxygen bridged bicyclic ethers through the coupling of 4-(2-hydroxyethyl)cyclohex-3-enols with aldehydes in the presence of 10 mol% of molecular iodine in dichloromethane at 25 °C. This method is highly diastereoselective affording the corresponding bicyclic ethers, i.e. octahydro-4a,7-epoxyisochromenes in good yields with high selectivi...

We herein report the synthesis of 3-methyl-1,3-butanediol from isobutene and HCHO in water via a Prins condensation-hydrolysis reaction over CeO2, which is a water-tolerant Lewis acid catalyst. The CeO2 exhibits significant catalytic activity for the reaction, giving 95% HCHO conversion and 84% 3-methyl-1,3-butanediol selectivity at 150 ◦C for 4 h. The crystal planes of CeO2 have a significant ...

In this paper it is shown that using the maximum likelihood ML prin ciple for the estimation of multivariate probit models leads to consistent and normally distributed pseudo maximum likelihood regression parame ter estimators PML estimators even if the true correlation structure of the responses is misspeci ed As a consequence e g the PML estimator of the random e ects probit model may be used...

Uscarea prin pulverizare este o metodă frecvent folosită la încapsularea microorganismelor probiotice. În prezentul studiu a fost utilizat duză ultrasonică de 120 kHz pentru a obţine granule foarte fine, care pot fi folosite în produse lactate probiotice. Celule de bacterii lactice au fost încapsulate în alginat şi maltodextrină prin atomizare cu ultrasunete. Încapsularea a fost realizată pentr...

6,19-Methanoprogesterone (4) was synthesized in nine steps from the readily available 3 beta,20 beta-diacetyloxy-5 alpha-bromo-6,19-oxidopregnane (5) in 14% overall yield. The additional carbon atom was introduced by reaction of a C-19 aldehyde with Ph3PCHOCH3 under salt free conditions and subsequent hydrolysis to give the homologous aldehyde. Intramolecular addition of the newly incorporated ...