In mammals, the primordial follicle pool represents the entire reproductive potential of a female. The transforming growth factor-β (TGF-β) family member activin (ACT) contributes to folliculogenesis, although the exact mechanism is not known. The role of FST288, the strongest ACT-neutralizing isoform of follistatin (FST), during cyst breakdown and primordial follicle formation in the fetal mic...

The microscopic quantum nature of elementary particles, chirality, leads to macroscopic phenomena like the chiral anomaly, magnetic effect, and plasma instability. We review recent progress studies these effects in high-energy astrophysics, such as pulsar kicks, magnetars, core-collapse supernovae, early Universe cosmology, primordial field, baryogenesis, gravitational waves. also provide a ped...

In female mammals, primordial follicles consist of two types of cells, namely, oocytes and pregranulosa cells that surround the oocytes. The size of the primordial follicle pool determines the reproductive ability of female mammals. However, the underlying mechanisms controlling primordial follicle assembly remain unclear. In this study, we show that oocyte-derived Janus kinase (JAK) signaling ...

The latest cosmological data seem to indicate a significant deviation from scale invariance of the primordial power spectrum when parameterized either by a power law or by a spectral index with non-zero “running”. This deviation, by itself, serves as a powerful tool to discriminate among theories for the origin of cosmological structures such as inflationary models. Here, we use a minimally-par...

Primordial germ cells are the founder cells of the gametes. They are set aside at the initial stages of gastrulation in mammals, become embedded in the hind-gut endoderm, then actively migrate to the sites of gonad formation. The molecular basis of this migration is poorly understood. Here we sought to determine if members of the integrin family of cell surface receptors are required for primor...

background: nandrolone decanoate (nd) is an anabolic androgenic steroid (aas) which influences the ovarian structure and function. we assessed the effects of nd on the ovarian volume, number of primordial follicles, and level of hormones and also evaluated the modulatory effects of gonadotropins on the histopathological changes imposed by the administration of nd. methods: six groups of sprague...