Vascular endothelial growth factors (VEGFs) are key regulators of permeability. The principal evidence behind how they increase vascular permeability in vivo and in vitro and the consequences of that increase are addressed here. Detailed analysis of the published literature has shown that in vivo and in vitro VEGF-mediated permeability differs in its time course, but has common involvement of m...

The problems of steady film condensation on a vertical surface embedded in a thin porous medium with anisotropic permeability filled with pure saturated vapour are studied analytically by using the Brinkman-Darcy flow model. The principal axes of anisotropic permeability are oriented in a direction that non-coincident with the gravity force. On the basis of the flow permeability tensor due to t...

BACKGROUND Rates of durable aneurysm occlusion following coil embolization vary widely, and a better understanding of coil mass mechanics is desired. The goal of this study is to evaluate the impact of packing density and coil uniformity on aneurysm permeability. METHODS Aneurysm models were coiled using either Guglielmi detachable coils or Target coils. The permeability was assessed by takin...

We investigated how pacing from different endocardial sites affects the left ventricular three-dimensional contraction pattern and performance in intact anesthetized dogs. We used data from the motion of radiopaque markers implanted in the left ventricular endocardium in an analysis based on the polar decomposition theorem to determine the left ventricle's three-dimensional principal directions...

The chemical features that impact small-molecule permeability across bacterial membranes are poorly understood, and the resulting lack of tools to predict permeability presents a major obstacle to the discovery and development of novel antibiotics. Antibacterials are known to have vastly different structural and physicochemical properties compared to nonantiinfective drugs, as illustrated herei...

BACKGROUND The cytokines TNF (TNFSF2) and IFNγ are important mediators of inflammatory bowel diseases and contribute to enhanced intestinal epithelial permeability by stimulating apoptosis and/or disrupting tight junctions. Apoptosis and tight junctions are also important for epithelial tissue morphogenesis, but the effect of TNF and IFNγ on the process of intestinal epithelial morphogenesis is...

The paper deals with the problem of motion planning of anthropomorphical mechanical hands avoidingcollisions. The proposed approach tries to mimic the real human hand workspace, but reducing the dimension ofthe search space in order to obtain results as a compromise between motion optimality and planning complexity(time) by means of the concept of principal motion directions. Basica...

A method that uses grain growth direction in electrodeposited copper foil to measure cyclic biaxial stress is examined in this paper. The grain growth direction is measured by image processing software after a cyclic loading test for various biaxial stress ratios is carried out. Since the grain growth occurs in two directions and its directions correspond closely with the direction of maximum s...

This Keynote Paper is concerned with the fundamental mechanics of granular materials with a particular reference to non-coaxial behaviour. The non-coaxial behaviour refers to the non-coincidence of principal stress directions and corresponding principal plastic strain rate directions during plastic deformation. At present, the majority of soil models used in geotechnical practice are those of a...

Newton’s third law of motion states that whenever a force is applied an equal and opposite force occurs in the opposite direction of applied force. Orthodontic tooth movement (OTM) being a biological phenomenon; sound knowledge of biomechanics is required. Sliding mechanics is a common approach in orthodontics to achieve tooth movement for closure and gaining of space.1,2 Sliding mechanics invo...