Case 1, an electrical engineer, had had recurrent gouty arthritis since the age of 14 years. A paternal uncle had also suffered with gout. From the age of 50 onwards numerous tophi appeared on the hands, feet, elbows, and ears. At one time or another he had been given various drugs, including corticosteroid hormones, phenylbutazone, salicylates, and probenecid. These drugs had produced no harmf...