Several nonparametric bootstrap methods are tested to obtain better confidence intervals for the quantitative trait loci (QTL) positions, i.e., with minimal width and unbiased coverage probability. Two selective resampling schemes are proposed as a means of conditioning the bootstrap on the number of genetic factors in our model inferred from the original data. The selection is based on criteri...

Maximum likelihood estimates of abundance are obtained from repeated photographic surveys of a closed stratified population with naturally marked and unmarked individuals. Capture intensities are assumed log-linear in stratum, year, and season. In the chosen model, an approximate confidence distribution for total abundance of bowhead whales, with an accompanying likelihood reduced of nuisance p...

Current methods used to analyze time to event data either rely on highly parametric assumptions which result in biased estimates of parameters which are purely chosen out of convenience, or are highly unstable because they ignore the global constraints of the true model. By using Targeted Maximum Likelihood Estimation (TMLE) one may consistently estimate parameters which directly answer the sta...

Applications in medical technology have a massive contribution to the treatment of patients. One attractive tools is ball bearings. These balls support load application as well minimize friction between surfaces. If heavy applied bearing, there risk that may be damaged and cause bearing fail earlier. Hence, we aim study model failure times A hybrid Type-II censoring scheme recommended experimen...

In this paper we explore the potential of multilevel models for meta-analysis of trials with binary outcomes for both summary data, such as log-odds ratios, and individual patient data. Conventional fixed effect and random effects models are put into a multilevel model framework, which provides maximum likelihood or restricted maximum likelihood estimation. To exemplify the methods, we use the ...

Molecular clocks have been used to date the divergence of humans and chimpanzees for nearly four decades. Nonetheless, this date and its confidence interval remain to be firmly established. In an effort to generate a genomic view of the human-chimpanzee divergence, we have analyzed 167 nuclear protein-coding genes and built a reliable confidence interval around the calculated time by applying a...

Sometimes the quality of a process or product is described by a functional relationship between a response variable and one or more explanatory variables referred to as profile. In most researches in this area the response variable is assumed to be normally distributed; however, occasionally in certain applications, the normality assumption is violated. In these cases the Generalized Linear Mod...

When using likelihood methods to quantify and to assess pooled data sets – thus assuming independence of dyads (S8 Text) – we explicitly allow m to vary across replicates while estimating a single RCP value in the likelihood-maximization process. When using bootstrap methods (S7 Text), as we do whenever individual-molecule data are available, we do not explicitly account for the possibility tha...