In this work, an auto-tuning procedure for PID controllers is presented. This autotuning procedure identifies a FOPDT model for a given process and uses an evolutionary algorithm to solve a constrained non-convex optimization problem to adjust the parameters of a PID controller with derivative filter. The auto-tuning procedure is validated with a set of process with different characteristics. P...

Auto-reactive cells-mediated immune responses are responsible for the current tissue damages during autoimmunity. Accordingly, functional modulation of auto-reactive cells has been a pivotal aim in many of recent studies. In the current study, we investigated the possibility for insertion of regulatory molecules onto auto-reactive cells through exosomal nano-shuttles as a novel approach for phe...

Autoinflammatory diseases area group of clinical conditions other than autoimmune diseases, characterized by recurrent inflammatory episodes. From apathogenetic point of view they are determined by a dys regulation of innate immunity, without involvement of specific immunity (auto reactive T cells and auto antibodies). Recently, the increased knowledge in the field of auto inflammation highligh...

BACKGROUND Adolescents with severe allergies are at particular risk of severe and fatal anaphylactic reactions. Epinephrine (adrenaline) is known to be under-utilized by teenagers. OBJECTIVE We sought to gain knowledge of adolescents' attitudes towards and experience of epinephrine auto-injectors in order to inform improvements in patient education. METHODS A qualitative study of adolescent...

BACKGROUND In view of the increasing prevalence of food allergies, there has been an associated increase in frequency of situations requiring an emergency response for anaphylaxis at the home, childcare facilities and educational institutions. OBJECTIVE To clarify the situation of adrenaline auto-injector administration in nursery/kindergarten/school, we carried out a questionnaire survey on ...

Malignant melanoma is one of the most aggressive types of tumor. Because malignant melanoma is difficult to treat once it has metastasized, early detection and treatment are essential. The search for reliable biomarkers of early-stage melanoma, therefore, has received much attention. By using a novel method of screening tumor antigens and their auto-antibodies, we identified bullous pemphigoid ...

In information retrieval, query auto completion (QAC), also known as typeahead [Xiao et al., 2013, Cai et al., 2014b] and auto-complete suggestion [Jain and Mishne, 2010], refers to the following functionality: given a prefix consisting of a number of characters entered into a search box, the user interface proposes alternative ways of extending the prefix to a full query. Ranking query complet...

The continuing evolution of Graphics Processing Units (GPU) has shown rapid performance increases over the years. But with each new hardware generation, the constraints for programming them efficiently have changed. Programs have to be tuned towards one specific hardware to unleash the full potential. This is time consuming and costly as vendors tend to release a new generation every 18 months....