ANTIANDROGENIC EFFECT OF SPIRONOLACTONE I. STUDIES ON SPIRONOLACTONE-INDUCED ALTERATIONS IN THE PLASMA HORMONAL PATTERNS Shiro Baba Department of Urology, School of Medicine, Keio University, Tokyo, Japan (Director: Prof. Hiroshi Tazaki.) Spironolactone, an aldosterone antagonist has an antiandrogenic effect by potentially inhibiting some enzymatic steps in androgen synthesis in testes and adre...

The aim of the study was to investigate the effect of tail-docking on the LH pulse frequency in femaleTuj lambs. Twelve female lambs were assigned into two equal groups. A rubber ring was applied to the baseof the tail for shedding off. Blood samples were collected for 8 h in the 4th and 8th months of age todetermine pulsatile secretion of LH. Starting from the age of 6 months, blood samples we...

The antitumor agent cisplatin and progesterone separate joint action on content of total phospholipids their individual fractions in nuclei from rat thymus cells were investigated. When used separately, exhibit its own distinctive properties. Cisplatin reduces, progesterone, the contrary, increases phospholipids. together, effects these drugs are summed up. Thus phospholipid cell by 17% after i...