نتایج جستجو برای: progesterone receptor gene

تعداد نتایج: 1591587  

2016
Yanfen Li Malavika K. Adur Athilakshmi Kannan Juanmahel Davila Yuechao Zhao Romana A. Nowak Milan K. Bagchi Indrani C. Bagchi Quanxi Li

Endometriosis, defined as growth of the endometrial cells outside the uterus, is an inflammatory disorder that is associated with chronic pelvic pain and infertility in women of childbearing age. Although the estrogen-dependence of endometriosis is well known, the role of progesterone in development of this disease remains poorly understood. In this study, we developed a disease model in which ...

Mandana Beigi Boroujeni Mohammadreza Gholami, Nasim Beigi Boroujeni,

Objective(s): Progestrone is a prequisite for pre-implantation angiogenesis and induce decidual angiogenesis. It is unknown the effect of progestrone administration on the endometrium of hyperstimulated mice at pre-implantation time. Material and Methods: Adult female NMRI mice were divided in three groups [control group, ovarian stimulated group and progestrone treated mice after ovarian stimu...

Journal: :Cancer research 1988
P D Feil C L Clarke P G Satyaswaroop

Monoclonal antibodies were used to investigate progesterone receptor structure (isoforms) in 33 primary human endometrial tumors. The monoclonal antibodies recognized on protein blots two progesterone receptor proteins with molecular weights of 116,000 and 81,000. The Mr 116,000 protein appeared as a triplet, while a single band was found for the Mr 81,000 protein. The triplet/singlet structure...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 1998
C A Moffatt E F Rissman M A Shupnik J D Blaustein

Mice, rats, and humans have two types of estrogen receptors, estrogen receptor-alpha (ERalpha) and estrogen receptor-beta (ERbeta). Estrogen receptor-alpha gene-disrupted (ERalpha-disrupted) mice bear two nonfunctional copies of the ERalpha gene. This mutation blocks the synthesis of full-length ERalpha, renders the animals infertile, and inhibits the induction of female sexual behaviors by est...

Journal: :Cancer research 2004
Bert Gold Francis Kalush Julie Bergeron Kevin Scott Nandita Mitra Kelly Wilson Nathan Ellis Helen Huang Michael Chen Ross Lippert Bjarni V Halldorsson Beth Woodworth Thomas White Andrew G Clark Fritz F Parl Samuel Broder Michael Dean Kenneth Offit

Nearly one in eight US women will develop breast cancer in their lifetime. Most breast cancer is not associated with a hereditary syndrome, occurs in postmenopausal women, and is estrogen and progesterone receptor-positive. Estrogen exposure is an epidemiologic risk factor for breast cancer and estrogen is a potent mammary mitogen. We studied single nucleotide polymorphisms (SNPs) in estrogen r...

Journal: :Prostaglandins & other lipid mediators 2005
U Tiemann K Bücher Ch Pfarrer R Pöhland F Becker W Kanitz P Schmidt

Platelet-activating factor (PAF) and its receptors are involved in inflammatory-like processes of the uterus associated with increased vascular permeability. PAF is supposed to be influenced by ovarian steroid hormones. The present study was undertaken to examine whether progesterone (P(4)), estradiol (E(2)) or PAF influence the PAF receptor gene expression in perfused endometrial explants deri...

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