Introduction: Glioblastoma multiforme (GBM) is the most common and aggressive primary malignant brain tumor found in adults. GBM has limited therapeutic options. Initial sampling establishes histopathologic diagnosis, identifies prognostic biomarkers, provides an opportunity for molecular profiling. By contrast, utility of repeat profiling recurrent not well established.

Most of the cancers that arise in the mucosa of the upper aerodigestive tract, including the oral cavity, pharynx, and larynx, are squamous cell carcinomas. To date, although there are no primary mutations that have been discovered to cause these cancers, aberrant expression of a variety of molecules characterizes head and neck squamous cell carcinoma (HNSCC). Most of the studies have compared ...

EK There are 4 biopsy-based biomarker tests on the market for men who have not undergone surgery: Oncotype DX prostate cancer test from Genomic Health, Decipher Biopsy from GenomeDx, Prolaris from Myriad Genetics, and ProMark from Metamark Genetics (Table). The way they work is that a biopsy sample is sent to the company laboratory, which analyzes the expression of various genes in the prostate...

Traumatic brain injury (TBI) represents one of the greatest unmet needs in medicine and public health (Maas et al., 2008). It is a major cause of death and disability and leads to great personal suffering to victims and relatives, as well as huge direct and indirect costs to society (Finkelstein et al., 2006; Faul et al., 2007; Gustavsson et al., 2011). TBI is considered “the most complex disea...

PURPOSE Aberrant DNA methylation, now recognized as a contributing factor to neoplasia, often shows definitive gene/sequence preferences unique to specific cancer types. Correspondingly, distinct combinations of methylated loci can function as biomarkers for numerous clinical correlates of ovarian and other cancers. EXPERIMENTAL DESIGN We used a microarray approach to identify methylated loci...

presented as: A Multimarker Strategy for Risk Prediction in Heart Failure: Application of Novel Methods in a Community Cohort. American Heart Association 2008 Scientific Sessions, Elizabeth-Barrett Connor Award Finalist, Oral Presentation November 9, 2008. New Orleans, LA. Word Count: Total 5992 Tables: 4 Figures: 1 Journal Subject Codes: [8] Epidemiology, [110] Congestive Heart Failure by gest...

In rheumatic diseases, biomarkers may serve as surrogate endpoints for diagnosis, prognosis, disease activity, therapeutic response and disease outcome. In recent years a great effort has been made to identify useful tools to establish early diagnosis, prognosis and therapeutic response especially in rheumatoid arthritis (RA). In psoriatic arthritis (PsA) serological biomarkers have been freque...

PURPOSE This paper describes a process for the identification of genes that can report on the aggressiveness of prostate tumors and thereby add to the information provided by current pathologic analysis. MATERIALS AND METHODS Expression profiling data from over 100 laser capture microdissection derived samples from nonneoplastic epithelium; Gleason patterns 3, 4, and 5 and node metastasis pro...

High-grade serous ovarian carcinoma (HGSC) accounts for 70% of all epithelial ovarian cancers but clinical management is challenged by a lack of accurate prognostic and predictive biomarkers of chemotherapy response. This study evaluated the role of Signal Transducer and Activator of Transcription 1 (STAT1) as an independent prognostic and predictive biomarker and its correlation with intratumo...

The melanoma staging system proposed by the American Joint Committee on Cancer (AJCC) (which classifies melanoma patients into four clinical stages) is currently the most widely used tool for melanoma prognostication, and clinical management decision making by clinicians. However, multiple studies have shown that melanomas within specific AJCC Stages can exhibit varying progression and clinical...