The enhanced microdialysis relative recovery (RR) of some hydrophobic tricyclic drugs (imipramine, desipramine, amitriptyline, carbamazepine and promethazine) is discussed. Enhanced RR was achieved by including a binding agent [beta-cyclodextrin (beta-CD) or 2-hydroxypropyl-beta-cyclodextrin (HP-beta-CD)] in the microdialysis perfusion fluid to form inclusion complexes with the drugs, which inc...

THE benefits to both patient and surgeon followed until either their discharge home, conferred by the use of phenothiazine derivatives in anaesthesia are so great that a report on the routine use of these drugs with pethidine as a sole or main anaesthetic agent for adults in general, uroor to a convalescent or other hospital, or until the end of the third week after operation. The types of oper...

Objective: Evidence base for rapid tranquillisation is an under researched area. Guidelines on rapid tranquilisation from English speaking countries were appraised using AGREE (Appraisal of Guidelines Research and Evaluation) and differences in their recommendations were analysed. Methods: Four independent psychiatrists appraised the guidelines using the AGREE tool. AGREE is a validated instrum...

Joseph Molnár1, Yvette Mándi1, Gabriella Spengler1, Ibolya Haszon3, Sándor Turi3, Miklós Kásler4, and Leonard Amaral1,2,* 1Department of Medical Microbiology and Immunobiology, University of Szeged, Szeged, Hungary 2Travel Medicine of the CMDT (Centro de Malaria e Doencas Tropicais), Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, Lisbon, Portugal 3Department of Pediatric...

Purpose: To optimize and formulate promethazine theoclate fast-dissolving tablets that offer a suitable approach to the treatment of nausea and vomiting. Method: The solubility of promethazine theoclate was increased by formulating it as a fast-dissolving tablet containing β-cyclodextrin, crospovidone, and camphor, using direct compression method. A 3 3 full factorial design was used to investi...

BACKGROUND Mice allergic to ovalbumin (OVA) avoid drinking a solution containing this antigen. This was interpreted as related to IgE-dependent mast cell degranulation and sensory C fiber activation. METHODS We employed pharmacological manipulation to further investigate the mediators involved in immune-induced food aversion. RESULTS While nonimmunized rats preferred a sweetened OVA solutio...

A new assay method has been developed for the quantitation of promethazine (PMZ) with a sensitivity and reproducibility as good as any previously reported method. This method is also capable of quantitatively determining three metabolites of PMZ (monodemethylated, sulphoxidated, and monodemethylated sulphoxidated PMZ), which has not been previously described. The method uses high-performance li...