The hair-growth cycle is an example of a cyclic process that is well characterized morphologically but understood incompletely at the molecular level. As an initial step in discovering regulators in hair-follicle morphogenesis and cycling, we used DNA microarrays to profile mRNA expression in mouse back skin from eight representative time points. We developed a statistical algorithm to identify...

Background: Cortisol is a crucial hormone for adaptation to challenging and stressful situations. Hair cortisol measurement used determine chronic stress; the growth rate of hair allows de...

714 P&T® • December 2005 • Vol. 30 No. 12 NEW DRUGS Eflornithine for Excess Facial Hair in Women Barrier Therapeutics has launched eflornithine HCl cream 13.9% (Vaniqua®) in Canada. The company acquired the exclusive right to distribute this product from Shire in June 2005. This is the only topical prescription product approved by Health Canada for slowing the growth of unwanted facial hair in ...

Sir, An important though rare side effect of reconstruction surgery in oral cavity is persistent hair growth in the recipient site due to intact hair follicles.[1] Hair growth in the transplanted site may be due to the dominant nature of the underlying skin.[2] A 40‐year‐old male came to the dermatology outpatient department with a complaint of excessive hair growth in the oral cavity 2 months ...

Hair follicles undergo continuous cycles of growth, involution and rest. This process, referred to as the hair growth cycle, has a periodicity of weeks to months. At the same time, skin and hair follicles harbor a functional circadian clock that regulates gene expression with a periodicity of approximately twenty four hours. In our recent study we found that circadian clock genes play a role in...

BACKGROUND Alopecia areata is the hair loss usually reversible, in sharply defined areas. The treatment of alopecia using growth factors shows interesting activity in promoting hair growth. In this concept, VEGF (vascular endothelial growth factor) is a marker of angiogenesis, stimulating hair growth by facilitating the supply of nutrients to the hair follicle, increasing follicular diameter. T...

Corticotropin-releasing factor (CRF) signaling pathways are involved in the stress response, and there is growing evidence supporting hair growth inhibition of murine hair follicle in vivo upon stress exposure. We investigated whether the blockade of CRF receptors influences the development of hair loss in CRF over-expressing (OE)-mice that display phenotypes of Cushing's syndrome and chronic s...

Androgens have profound effects on scalp and body hair in humans. Scalp hair grows constitutively in the absence of androgens, while body hair growth is dependent on the action of androgens. Androgenetic alopecia, referred to as male pattern hair loss (MPHL) in men and female pattern hair loss (FPHL) in women, is due to the progressive miniaturization of scalp hair. Observations in both eunuchs...

Today considerable consumer interest has risen towards the use of herbal hygienic and cosmetic products. Lavender oil is a well-known essence with uses in the treatment of alopecia, dandruff and scalp hair re-growth, as well as possessing antimicrobial, antiviral and antifungal effects. Hence, this study was undertaken to formulate and assess the efficacy of a new clear liquid hair shampoo cont...

Previous molecular genetic studies of the goat hair life cycle have focused primarily on a limited number of genes and proteins. To identify additional genes that may play important roles in hair follicle cycle regulation, Illumina sequencing technology was used to catalog differential gene expression profiles in the hair growth cycle (anagen to catagen) of goat, comparing the primary hair foll...