Acute kidney injury (AKI) is characterized by high mortality rates from deterioration of renal function over a period of hours or days that culminates in renal failure. AKI can be caused by a number of factors including ischemia, drug-based toxicity, or obstructive injury. This results in an inability to maintain fluid and electrolyte homeostasis. While AKI has been observed for decades, effect...

The Wilms' tumor suppressor gene Wt1 encodes a zinc-finger transcription factor that plays an essential role in organ development, most notably of the kidney. Despite its importance for organogenesis, knowledge of the regulation of Wt1 expression is scarce. Here, we have used transgenesis in zebrafish harboring two wt1 genes, wt1a and wt1b, in order to define regulatory elements that drive wt1 ...

The major lymphoid tissues in teleost fish are the kidneys, thymus, spleen and mucosa-associatedlymphoid tissue including the skin, gills and intestine. The head of kidney (pronephros) is an importanthaematopoietic organ and has morphological similarities with the bone marrow in higher vertebrates. In thisstudy, during 12 months from August 2002 to July 2003, 120 grass carp (10 fish/month) were...

The early development of the mesoblast in the intermediate and lateral regions of the chick embryo was examined with the scanning and transmission electron microscope. It was found that primary mesenchyme here becomes condenses into epithelial structures that emerge in a metameric pattern. Viewed in developmental sequence, the intermediate mesoblast condenses into a narrowing cord of axially or...

Greater amberjack ( Seriola dumerili ) is an important commercial fish for its high growth rate and excellent flesh quality. However, sensitivity to variations of water salinity poses challenges the cage culture. In this study, greater were reared in optimum (30 ppt, CK) undesired regimes (10 40 ppt) 72 hours. The molecular adaptive mechanisms stress revealed by comparative transcriptome analys...