نتایج جستجو برای: prorenin receptor
تعداد نتایج: 590644 فیلتر نتایج به سال:
Mouse submandibular gland prorenin-converting enzyme (PRECE) consists of the two polypeptide chains of 17 and 10 kDa and cleaves mouse Ren-2 prorenin at a dibasic site to yield mature renin. Western blot analysis using an antiserum against this enzyme gave rise to multiple bands in mouse submandibular glands, suggesting that PRECE is a member of a protease family. Partial amino acid sequence an...
We have identified and characterized an anti-human renin monoclonal antibody R1-20-5 that is selective for human active renin. R1-20-5 binds active renin with a dissociation constant (Kd) of 2.5 x 10(-7) M/l and inhibits renin enzymatic activity with an inhibitory constant (IC50) of 1.4 x 10(-8) M/l. R1-20-5 competes with a synthetic renin inhibitor for binding with renin, demonstrating further...
ly playing a role in granule formation, the glycosylation state of renin may also be important for mannose-6phosphate receptor-mediated uptake of renin or prorenin in other tissues, such as the heart (62, 93). Protogranules that are destined for the regulated secretory pathway pinch off from the trans-Golgi network. They contain prorenin and proteases, such as prohormone convertases (1, 5) and ...
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