Protein-protein interaction (PPI) networks are essential to understand the fundamental processes governing cell biology. Recently, studying PPI networks becomes possible due to advances in experimental high-throughput genomics and proteomics technologies. Many interactions from such high-throughput studies and most interactions from small-scale studies are reported only in the scientific litera...

In this work we address the problem of predicting proteinprotein interactions. Its solution can give greater insight in the study of complex diseases, like cancer, and provides valuable information in the study of active small molecules for new drugs, limiting the number of molecules to be tested in laboratory. We model the problem as a binary classification task, using a suitable coding of the...

Automatic detecting protein-protein interaction (PPI) relevant articles is a crucial step for large-scale biological database curation. The previous work adopted POS tagging, shallow parsing and sentence splitting techniques, but they achieved worse performance than the simple bag-of-words representation. In this paper, we generated and investigated multiple types of feature representations in ...

The classification of proteins based on their structure plays an important role in the deduction or discovery of protein function. Furthermore, the large number of potential classes causes problems for many classification strategies, increasing the likelihood that the classifier will reach local optima while trying to distinguish between all of the possible structural categories. In this paper,...

Protein classification is one of the critical problems in bioinformatics. Early studies used geometric distances and polygenetic-tree to classify proteins. These methods use binary trees to present protein classification. In this paper, we propose a new protein classification method, whereby theories of information and networks are used to classify the multivariate relationships of proteins. In...

Data mining techniques have been used by researchers for analyzing protein sequences. In protein analysis, especially in protein sequence classification, selection of feature is most important. Popular protein sequence classification techniques involve extraction of specific features from the sequences. Researchers apply some well-known classification techniques like neural networks, Genetic al...

The classification of protein folds is necessarily based on the structural elements that distinguish domains. Classification of protein domains consists of two problems: the partition of structures into domains and the classification of domains into sets of similar structures (or folds). Although similar topologies may arise by convergent evolution, the similarity of their respective folding pa...