نتایج جستجو برای: protein phosphorylation
تعداد نتایج: 1273592 فیلتر نتایج به سال:
Melatonin (MLT) is a biologically active indoleamine involved in regulating various biological rhythms, which deficient individuals with Type 2 diabetes. The present study examined the effects of MLT on diabetic neuropathy (DN). Diabetic rats received treatment for 12 weeks, after changes kidney histology, oxidative damage, mitochondrial morphology and autophagy were measured. glucose tolerance...
Glycoproteins GPVI and GPIb-IX-V stimulate robust tyrosine phosphorylation of Syk and PLCg2 (phospholipase Cg2) in washed platelets, but only the former stimulates pronounced activation of phospholipase. Using phospho-specific antibodies, we demonstrate that GPVI, but not GPIb-IX-V, stimulates significant tyrosine phosphorylation of Syk at the autophosphorylation site pY525/526, a marker of Syk...
Multi-omics analyses reveal that HIV-1 alters CD4+ T cell immunometabolism to fuel virus replication
Individuals infected with human immunodeficiency virus type-1 (HIV-1) show metabolic alterations of CD4+ T cells through unclear mechanisms undefined consequences. We analyzed the transcriptome from patients HIV-1 and revealed that elevated oxidative phosphorylation (OXPHOS) pathway is associated poor outcomes. Inhibition OXPHOS by US Food Drug Administration–approved drug metformin, which targ...
Poly(A) polymerase (PAP), which adds poly(A) tails to the 3' end of mRNA, can be phosphorylated at several sites in the C-terminal domain. Phosphorylation often mediates regulation by extracellular stimuli, suggesting PAP may be regulated by such stimuli. In this study, we found that phosphorylation of PAP was increased upon growth stimulation and that the mitogen-activated protein kinase ERK w...
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