Identification of Plasmid-Mediated AmpC -Lactamases in Escherichia coli, Klebsiella spp., and Proteus Species Can Potentially Improve Reporting of Cephalosporin Susceptibility Testing Results Fred C. Tenover, Shannon L. Emery, Carol A. Spiegel, Patricia A. Bradford, Samantha Eells,† Andrea Endimiani, Robert A. Bonomo, and John E. McGowan, Jr.* Division of Healthcare Quality Promotion, Centers f...

SYNOPSIS The properties and characteristics of 296 Proteus strains isolated from hospital patients and from sewage have been examined with a view to determining those characters which are of most use in following and detecting cross-infection. Ninety-six per cent of the organisms isolated were P. mirabilis and it was found that by identifying biotypes and by phage typing the species could be di...

Marjorie J. Lindhurst1, Ji-an Wang2, Hadley M. Bloomhardt1, Alison M. Witkowski1, Larry N. Singh1, David P. Bick3, Michael J. Gambello4, Cynthia M. Powell5, Chyi-Chia Richard Lee6, Thomas N. Darling2, and Leslie G. Biesecker1 1National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA 2Department of Dermatology, Uniformed Services University of the Health Science...

BACKGROUND The Proteus syndrome is characterized by the overgrowth of skin, connective tissue, brain, and other tissues. It has been hypothesized that the syndrome is caused by somatic mosaicism for a mutation that is lethal in the nonmosaic state. METHODS We performed exome sequencing of DNA from biopsy samples obtained from patients with the Proteus syndrome and compared the resultant DNA s...