OBJECTIVES To review randomised controlled trials of treatment with a proton pump inhibitor in patients with ulcer bleeding and determine the impact on mortality, rebleeding, and surgical intervention. DESIGN Systematic review and meta-analysis. DATA SOURCES Cochrane Collaboration's trials register, Medline, and Embase, handsearched abstracts, and pharmaceutical companies. REVIEW METHODS ...

AIM We conducted a retrospective non-interventional cohort study to analyze the impact of proton pump inhibitors co-administration on methotrexate elimination in cancer patients receiving treatment protocol with the antifolate at high dose (>1 g/m(2) intravenously). PATIENTS AND METHODS Between 2005 and 2008, 79 patients (mean age: 48.8 years; range: 16-76 years) were treated by high dose met...

OBJECTIVE To evaluate the efficacy of treatment for gastro-oesophageal reflux disease (GORD) on chronic cough in children and adults without an underlying respiratory disease. DESIGN Systematic review and meta-analysis. DATA SOURCES Cochrane, Medline, and Embase databases, references from review articles. INCLUDED STUDIES Randomised controlled trials on GORD treatment for cough in childre...

BACKGROUND The prevalence of celiac disease and the use of medications that inhibit acid secretion have both increased in recent decades. AIM To explore the association between antisecretory medication exposure and subsequent development of celiac disease. METHODS In this population-based case control study, we identified patients with celiac disease diagnosed at all pathology departments i...

Endoscopic submucosal dissection has made it possible to resect large lesions during a single operation. The present study was undertaken to compare the time taken for recovery from artificial ulcers after endoscopic submucosal dissection between an H(2) Receptor Antagonist treatment group and a Proton Pump Inhibitor treatment group, focusing on analysis of the time course of reduction rate in ...

AIM To perform a systematic review on the efficacy of intermittent and on-demand therapy with either histamine H2-receptor antagonists or proton pump inhibitors for patients with erosive oesophagitis or symptomatic heartburn. METHOD We conducted randomized-controlled trials of non-continuous therapy in gastro-oesophageal reflux disease patients. RESULTS Fourteen studies met inclusion criter...

Acid-peptic disease is widely considered conquered or controlled, future advances being refinements of existing treatments rather than radical new developments. Yet controversies remain and developments have yet to be made. DUODENAL ULCER: Daily maintenance treatment with the anti-secretory drugs, histamine H2 receptor antagonists and proton pump blockers, controls duodenal ulcer effectively, m...

Background: P-type proton pumps work against large electrochemical gradients, but how gating is controlled is poorly understood. Results: Substitution of Asn106 in transmembrane segment M2 significantly reduces the ability of the pump to perform uphill proton transport. Conclusion: Asn106 fulfills several criteria for being a gating residue in P-type proton pumps. Significance: The presence of ...

The development of line-narrowing techniques, such as magic-angle spinning (MAS) and high-power decoupling, has led to powerful high-resolution nuclear magnetic resonance approaches for solid samples. In favorable cases (for instance, where high abundances of protons are present) cross polarization (CP) provides a means of circumventing the time bottleneck caused by inefficient spinlattice rela...

The mechanism of oxidative phosphorylation is well understood, but evolution of the proteins involved is not. We combined phylogenetic, genomic, and structural biology analyses to examine the evolution of twelve mitochondrial encoded proteins of closely related, yet phenotypically diverse, Pacific salmon. Two separate analyses identified the same seven positively selected sites in ND5. A strong...