By using tissue microdissection and polymerase chain reaction (PCR) techniques, we examined 85 prostate tumors that were paired with normal tissues from the same patients for allelic loss at 26 highly polymorphic microsatellite sequences, 21 spanning 8p and 5 localized to 8q. Sixty-four tumors (75%) demonstrated loss of at least one 8p locus. Separate distal and proximal regions of deletion wer...

Here we study non-convex composite optimization: first, a finite-sum of smooth but non-convex functions, and second, a general function that admits a simple proximal mapping. Most research on stochastic methods for composite optimization assumes convexity or strong convexity of each function. In this paper, we extend this problem into the non-convex setting using variance reduction techniques, ...

We performed color Doppler flow mapping in 15 patients, 1 week to 17 years old (mean 42 months), with coarctation of the aorta that was confirmed subsequently by angiography and/or surgery. Twelve patients had native coarctation and three had mild recoarctation after surgical repair. Color Doppler flow maps were analyzed with a digital analysis package and a Sony computer system. The diameter i...

Genetic linkage studies have implicated at least two loci for X-linked retinitis pigmentosa (XLRP) on proximal Xp. We now report a defined genetic localization for the RP2 locus to a 5-cM interval in Xp11.3-11.23. Haplotype analysis of polymorphic markers in recombinant individuals from two XLRP families has enabled us to identify DXS8083 and DXS6616 as the new distal and proximal flanking mark...

Abstract In this paper, we present new iterative techniques for approximating the solution of an equilibrium problem involving a pseudomonotone and Lipschitz-type bifunction in Hilbert spaces. These consist two computing steps proximal-type mapping with inertial term. Improved simplified stepsize rules that do not involve line search are investigated, allowing method to be implemented more quic...

In humans, there is clear evidence of an association between hip fracture risk and femoral neck bone mineral density, and some evidence of an association between fracture risk and the shape of the proximal femur. Here, we investigate whether the femoral cortex plays a role in these associations: do particular morphologies predispose to weaker cortices? To answer this question, we used cortical ...

A new monotonicity, M-monotonicity, is introduced, and the resolvant operator of an M-monotone operator is proved to be single-valued and Lipschitz continuous. With the help of the resolvant operator, the positively semidefinite general variational inequality (VI) problem VI (S+,F +G) is transformed into a fixed point problem of a nonexpansive mapping. And a proximal point algorithm is construc...

The purpose of this paper is to introduce and consider new hybrid proximal-type algorithms for finding a common element of the set EP of solutions of a generalized equilibrium problem, the set F S of fixed points of a relatively nonexpansive mapping S, and the set T−10 of zeros of a maximal monotone operator T in a uniformly smooth and uniformly convex Banach space. Strong convergence theorems ...

Previous complementation analyses with five (c11DSD, c5FR60Hg, c2YPSj, c4FR60Hd, c6H) of the mouse albino deletions defined at least two genes on chromosome 7, known as eed and exed, which are necessary for development of the embryonic and extraembryonic ectoderm, respectively, of early postimplantation embryos. The region of chromosome 7 containing these two genes has now been accessed at the ...