The [PSI(+)] nonsense-suppressor determinant of Saccharomyces cerevisiae results from the ability of Sup35 (eRF3) translation termination factor to undergo prion-like aggregation [1]. Although this process is autocatalytic, in vivo it depends on the chaperone Hsp104, whose lack or overexpression can cure [PSI(+)] [2]. Overproduction of the chaperone protein Ssb1 increased the [PSI(+)] curing by...

The induction of the isiA (CP43') protein in iron-stressed cyanobacteria is accompanied by the formation of a ring of 18 CP43' proteins around the photosystem I (PSI) trimer and is thought to increase the absorption cross section of PSI within the CP43'-PSI supercomplex. In contrast to these in vitro studies, our in vivo measurements failed to demonstrate any increase of the PSI absorption cros...

Hsp104 is a hexameric protein chaperone that resolubilizes stress-damaged proteins from aggregates. Hsp104 promotes [PSI(+)] prion propagation by breaking prion aggregates, which propagate as amyloid fibers, into more numerous prion "seeds." Inactivating Hsp104 cures cells of [PSI(+)] and other amyloid-like yeast prions. Overexpressing Hsp104 also eliminates [PSI(+)], presumably by completely r...

Although the application of patient-specific instruments (PSI) for total knee arthroplasty (TKA) increases the cost of the surgical procedure, PSI may reduce operative time and improve implant alignment, which could reduce the number of revision surgeries. We report our experience with TKA using PSI techniques in 120 patients from March to December 2014. PSI for TKA were created from data provi...

Photosystem I (PSI) is a pigment-protein complex located in the thylakoid membrane of cyanobacteria and chloroplasts of algae and higher plants, which functions as a plastocyanin (or cytochrome c6)-ferredoxin oxidoreductase. The reducing potential of ferredoxin is utilized for a variety of biochemical processes such as the reduction of NADP, or the assimilation of nitrate or sulfate. In higher ...

Vpre-B and lambda 5 genes, respectively, encode V-like and C-like domains of a surrogate immunoglobulin light chain (psi L). Such psi L complex is expressed in early progenitor B (pro-B) cells, before conventional immunoglobulin heavy (microH) and light (L) chains are produced. We raised a wide panel of monoclonal antibodies (mAbs) against soluble recombinant Vpre-B proteins to study early even...

In Geometric function theory, occasionally, attempts have been made to solve a particular problem for the Ma-Minda classes, $$\mathcal {S}^*(\psi )$$ and {C}(\psi of univalent starlike convex functions, respectively. Recently, popular radius generally known as Bohr’s phenomenon has studied in various settings; however, little is about Rogosinski radius. this article, fixed $$f\in \mathcal or ),...

We utilized UV resonance Raman (UVRR) measurements and density functional theory (DFT) calculations to relate the AmII'p frequency to the psi angle. The AmII'p frequency shifts by approximately 25 cm(-1) as the psi angle is varied over allowed angles of the Pro peptide bond. The AmII'p frequency does not show any significant dependence on the phi dihedral angle. The conformation sensitivity of ...