Background and aim: Uremic pruritus is a relatively common and distressing problem for patients with chronic renal failure. Serotonin and histamine have been reported as possible mediators of uremic pruritus. Granisetron, a potent and selective inhibitor of 5-HT3 receptors was developed for relief of chemotherapy induced nausea. There are some studies about effect of Ondansetron in uremic...

conclusions dialysis with cool dialysate is a simple and cheap nondrug method, which was readily accepted by the patients. this method could significantly reduce the severity of pruritus in patients during dialysis. results before the intervention, there was no significant between-group difference in the severity of pruritus (p < 0.05). after the intervention, the severity of pruritus was signi...

Cholestatic pruritus is one of the most common complaints in patients with liver diseases and intraor posthepatic cholestasis. The mechanisms of cholestatic pruritus remain poorly understood although multiple factors are considered to participate in the pathogenesis of cholestatic pruritus. Recent exciting studies have discovered several G-protein coupled receptors (GPCRs) and endogenous chemic...

Pruritus occurs frequently in the elderly population, but it has not been fully defined and its precise prevalence is unknown. Putative causes of pruritus are numerous and patients' quality of life can be greatly reduced. In the absence of any specific cause, a diagnosis of senile pruritus is proposed, suggesting that itch is secondary to ageing. However, the relationship of pruritus with skin ...

Zusammenfassung Chronischer Pruritus ist ein häufiges Symptom mit einer Prävalenz von rund 15 %. Neben klassischen Hauterkrankungen wie der atopischen Dermatitis oder Psoriasis leiden auch zahlreiche Patienten internistischen, neurologischen und psychiatrischen Krankheitsbildern an Pruritus. Die häufigsten internistischen Ursachen des chronischen sind chronische Niereninsuffizienz, Leber- Galle...