Prostate cancer patients often have increased levels of psychological stress or anxiety, but the molecular mechanisms underlying the interaction between psychological stress and prostate cancer as well as therapy resistance have been rarely studied and remain poorly understood. Recent reports show that stress inhibits apoptosis in prostate cancer cells via epinephrine/beta2 adrenergic receptor/...

the distressing symptoms of psychosis, delusions, and hallucinations used to be thought of as unsuitable for psychological therapies. Recent research on the continuities between normal experiences and those found in psychosis has led to the development of a wider range of psychological therapies, adapted from approaches for anxiety and depression, to the more complex presentations found in psyc...

OBJECTIVE To compare the clinical effectiveness of general practitioner care and two general practice based psychological therapies for depressed patients. DESIGN Prospective, controlled trial with randomised and patient preference allocation arms. SETTING General practices in London and greater Manchester. PARTICIPANTS 464 of 627 patients presenting with depression or mixed anxiety and d...

OBJECTIVE To compare the cost effectiveness of general practitioner care and two general practice based psychological therapies for depressed patients. DESIGN Prospective, controlled trial with randomised and patient preference allocation arms. SETTING General practices in London and greater Manchester. PARTICIPANTS 464 of 627 patients presenting with depression or mixed anxiety and depre...

We describe the use of a number of outcome measures that have been used over the past eight years to evaluate adult psychological therapies services in the Wakefield & Pontefract locality of the South West Yorkshire Mental Health NHS Trust. The psychological therapies service now has a unique database of outcome measures completed by 5563 clients, which has been used nationally and internationa...

AIM To evaluate the outcomes of participants attending a psychological therapies service for military veterans. BACKGROUND The UK Military Veterans' Improving Access to Psychological Therapies Service (North West) (MV IAPT) provided a clinical psychological therapies service for military veterans. Outcomes of depression, anxiety and social adjustment were assessed after treatment in the servi...

This digest offers three analytical and review materials on efficacy of various psychological therapies for people with post-traumatic stress disorders. These recently published meta-analyses are based trials performed adults, children adolescents, patients complex trauma.

INTRODUCTION Worldwide, health systems are improving access to empirically supported psychological therapies for anxiety and depression. Evaluations of this effort are limited by the cross sectional nature of studies, short implementation periods, poor data completeness rates and lack of clinically significant and reliable change metrics. OBJECTIVE Assess the impact of implementing stepped ca...

BACKGROUND The efficacy of psychosocial therapies for common mental health disorders in veterans is unclear and requires further examination. METHOD Systematic review and meta-analyses of randomised controlled trials (RCTs). Twenty databases were searched. Studies were included if they reported a psychosocial intervention designed to treat or reduce common mental health symptoms in veterans i...