Being impermeable to folic acid, many bacteria must rely on their ability to synthesise folate from PABA, Pteridine, and glutamate in contrast the mammalian in cells cannot synthesise folic acid and must obtain preformed folate as a vitamin in their diet. The sulphonamides are structurally similar to PABA, the sulphonamides competitively inhibit dihydropteroate synthetase, the enzyme that catal...

aldose reductase is a critical enzyme in the polyol pathway that plays an important role in diabetes mellitus. inhibition of the activity of this enzyme can prevent cataract in diabetic patients’lenses. in this study the inhibitory effect of two flavonoids, quercetin and naringin, in the activity of aldose reductase in streptozotocin-induced diabetic and healthy rats were investigated. thirty m...

background: the association between methylene tetrahydrofolate reductase polymorphism and coronary artery diseases risk has been both confirmed and refuted in a number of published studies. the aim of this study was to investigate whether genetic polymorphisms of mthfr (c677t, a1298c) contributed to the development of myocardial infarction (mi). materials and methods: the present case-control s...