introduction: the role of brain tissues oxidative damage in learning and memory impairments has been well documented. it is also well known that thyroid hormones have a critical role for the brain functions. the purpose of this study was to investigate the role of brain tissues oxidative damage as a possible mechanism of deleterious effects of propylthiouracil (ptu) - induced hypothyroidism on ...

Abstract Background Polytobacco product use is increasingly popular, but little known about the prevalence, trend, and factors of such particularly in non-western countries. Method A representative sample 1139 current cigarette smokers aged 15+ (84.1% male) were telephone interviewed Tobacco Control Policy-related Surveys 2015–2017. Information collected included poly-tobacco (PTU), smoking soc...

The attachment of bacteria and other microbes to natural artificial surfaces leads the development biofilms, which can further cause nosocomial infections. Thus, an important field research is new materials capable preventing initial adhesion pathogenic microorganisms. In this work, novel polymer/particle composite materials, based on a polythiourethane (PTU) matrix either spherical (s-ZnO) or ...

Peningkatan kadar kolesterol Low-Density Lipoprotein (LDL) dapat menyebabkan plak pada dinding arteri dan menjadi faktor penyebab infark miokard. Tujuan penelitian ini adalah untuk mengetahui pengaruh pemberian air rebusan kombinasi daun ciplukan (Physalis angulate L.) salam (Syzygium polyanthum) terhadap LDL tikus putih (Rattus norvegicus) yang diinduksi Diet Tinggi Lemak (HFD) propiltiourasil...

Hypercholesterolemia is a condition in which cholesterol levels the blood are more than normal. Europe and America regions with highest hypercholesterolemia world prevalence values ​​of 54% 48%, respectively. Meanwhile, Africa Southeast Asia lowest of 23% 30%, In Indonesia, age group 25 - 34 years has rank high levels. The purpose this study was to determine effect lowering total male white rat...

Drug-induced autoimmunity provides a fascinating glimpse of the environment’s contribution to the development of anti-self reactivity. After a period of treatment, certain drugs induce, in a subset of individuals, clinical signs that are typically found only in autoimmune disorders. The clinical features of drug-induced autoimmunity are a reminder that genetic predisposition to self reactivity ...

Tiroid hastalıkları, gebelik esnasında kompleks hormonal değişiklikler nedeniyle yaygın olarak görülür. Fetal hidrops, düşük doğum ağırlığı, fetal distress ve nörofizyolojik gelişme geriliği açısından risklidir. 20 yaşında primigravid gebe hipotiroidizmle başvurdu ve bu esnada propiltiourasil (PTU) 3x1 kullanmaktaydı. Yapılan ultrasonografi (USG)’de hidrops fetalis görüldü ve bunun üzerine PTU ...

To determine the role of thyrotropin-releasing hormone (TRH) in the regulation of thyroid-stimulating hormone (TSH) secretion in the perinatal period, a physiological approach of neutralizing circulating TRH in the fetal and early neonatal rat was employed. TRH-antiserum (TRH-AS) raised in rabbits and administered daily to low iodine-propylthiouracil (LID-PTU)-fed pregnant rats from days 12 to ...

Parabiont rats were used to study the regulation of intestinal cholesterol synthesis (3-hydroxy-3-methylglutaryl coenzyme A [HMG-CoA] reductase activity) and esterification (acylcoenzyme A/cholesterol acyltransferase [ACAT] activity) by lipoproteins and micellar cholesterol. The parabiont rat model offers a unique way to observe changes in cholesterol metabolism in the intestine, independently ...