The burden of thrombotic diseases is heavy on the world population. It is widely known that coronary artery disease is amajor cause of death but many laymen do not know that the mortality is mediated by thrombosis on a ruptured plaque. It is also lesswell-known that stroke is commonly the result of a thrombus that might have embolized from the heart or the carotid artery or was sometimes genera...

A 38 years old male patient presented to the emergency department with acute severe retrosternal chest pain and was found to have pulmonary thromboembolism. The patient developed new necrotic lung cavities each day due to the dissemination of emboli from the thrombus. The cause of thrombus was found to be protein C deficiency, which is an inherited thrombophilia. The interesting features in thi...

BACKGROUND Acute pulmonary thromboembolism is fatal because of abruptly occurring hypoxemia and right ventricular failure. There are several treatment modalities, including anticoagulation, thrombolytics, ECMO (extracorporeal membrane oxygenator), and thromboembolectomy, for managing acute pulmonary thromboembolism. MATERIALS AND METHODS Medical records from January 1999 to December 2004 at o...

Pulmonary artery sarcoma mimicking chronic pulmonary thromboembolism Sarcoma da artéria pulmonar simulando tromboembolismo pulmonar crônico Dear Editor, A 35-year-old woman was admitted in our institution with a 2-year history of dyspnea, hemoptysis and chest pain. Chest computed tomography (CT) demonstrated filling defects in the right pulmonary artery and some of its branches (Figure 1A). Tra...

BACKGROUND Low-molecular-weight heparin is known to be safe and effective for the initial treatment of patients with proximal deep-vein thrombosis. However, its application to pulmonary embolism or previous episodes of thromboembolism has not been studied. METHODS We randomly assigned 1021 patients with symptomatic venous thromboembolism to fixed-dose, subcutaneous low-molecular-weight hepari...

Venous thromboembolism (VTE) and related pulmonary thromboembolism are life-threatening diseases that require efficient diagnosis and clinical management. While the diagnosis and treatment of VTE in hospitalized patients has been extensively studied, less has been reported on walk-in patients with VTE. Here we report on four outpatients with VTE that were efficiently diagnosed using the blood D...

OBJECTIVE Recently, the European Medicines Agency reported that strontium ranelate increases myocardial infarction risk in postmenopausal women, 8.5 years after it was registered for use in osteoporosis. Unreported serious adverse events in clinical trials for other pharmaceuticals have been described in recent years. We assessed reporting of adverse events and fracture efficacy of strontium. ...

Pulmonary thromboembolism (PTE) is a fatal condition that may rarely occur due to complications of coronary catheter insertion. In this case report, a 41-year-old male was presented 48 hours after radiofrequency catheter ablation(RFCA) for the management of Wolf-Parkinson-White syndromewith acute onset of dyspnea, hemoptysis, and chest pain. The physical examination revealed coarse crackles in ...

Men have been reported to have a higher incidence of recurrent venous thromboembolism than women. However, it is not known if this gender effect holds among different racial/ethnic groups and for both venous thrombosis and pulmonary embolism. We conducted a retrospective analysis of 18- to 65-year-old Caucasian, African-American and Hispanic cases hospitalized in California with unprovoked veno...