The central arteries stiffen with age, causing hemodynamic alterations that have been associated with cardiovascular events. Changes in body fat with age may be related to aortic stiffening. The association between vascular stiffness and body fat was evaluated in 2488 older adults (mean age, 74 years; 52% female; 40% black) enrolled in the Study of Health, Aging, and Body Composition (Health AB...

BACKGROUND Chronic obstructive pulmonary disease (COPD) is a progressive, chronic respiratory disease with a significant socioeconomic burden. Exacerbations, the sudden and sustained worsening of symptoms, can lead to hospitalization and reduce quality of life. Major limitations of previous telemonitoring interventions for COPD include low compliance, lack of consensus on what constitutes an ex...

Time series analysis can identify outliers in tree-ring widths that may not only indicate past disturbances, but may also estimate the subsequent effe cts of these disturbances on tree growth. Findin g a way to isolate these disturbance signals from tree-ring time series could have broad applications in forest ecology and management. Time series outliers may be expressed as pulse, step, or tren...

background: to manage relapsing‑remitting multiple sclerosis (ms) in the course of acute exacerbations, methylprednisolone (mp) (medrol or solu‑medrol), has the ability to lock the injured blood‑brain barrier and decrease irritation in the central nervous system. the aim of this preliminary study was to investigate the frequency and time interval related to mp pulse therapy in patients with ms....

BACKGROUND Pulse oximetry is a widely accepted procedure for ventilatory monitoring during gastrointestinal endoscopy, but this method provides an indirect measurement of the respiratory function. In addition, detection of abnormal ventilatory activity can be delayed, especially if supplemental oxygen is provided. Capnography offers continuous real-time measurement of expiratory carbon dioxide....

Deadlock can occur wherever multiple processes interact. Most existing static and dynamic deadlock detection tools focus on simple types of deadlock, such as those caused by incorrect ordering of lock acquisitions. In this paper, we propose Pulse, a novel operating system mechanism that dynamically detects various types of deadlock in application programs. Pulse runs as a system daemon. Periodi...

A simple technique is developed for determining the rupture duration and stress drop of earthquakes between magnitudes 3.5 and 4.0 using the time between the P-wave onset and the first zero crossing (71t2) on seismograms from local seismic networks. This method is applied to 10 main shocks in southern California to investigate regional variations in stress drop. The initial pulse widths of 65 f...

BACKGROUND Pulse pressure (PP) is a risk factor for cardiovascular disease. It has been reported that ambulatory blood pressure (BP) and nighttime BP parameters are heritable traits. However, the genetic association of pulse pressure and its clinical impact remain undetermined. METHOD AND RESULTS We conducted a genome-wide association study of PP using ambulatory BP monitoring in young-onset ...

Climate change is occurring globally, with wide ranging impacts on organisms and ecosystems alike. While most studies focus on increases in mean temperatures and changes in precipitation, there is growing evidence that an increase in extreme events may be particularly important to altering ecosystem structure and function. During extreme events organisms encounter environmental conditions well ...

AIMS Diabetes affects 29 million adults, and the majority have type 2 diabetes (T2D). Coronary artery disease (CAD) is the leading cause of death, and physical inactivity is an important risk factor. The aims of this study were to examine the contribution of physical inactivity to CAD events, and to identify the independent predictors of CAD events in a sample of older adults with T2D. METHOD...