We present a method for designing efficient multigenic predictors with few probes and its application to the prediction of the response to preoperative chemotherapy in breast cancer. In this study, each DNA probe was regarded as an elementary predictor of the response to the chemotherapy and the probes which were selected performed a faithful sampling of the training dataset. In a first stage o...

BACKGROUND An association between cigarette smoking and increased risk of clear cell renal cell carcinoma (ccRCC) has been established; however, there are limited data regarding the molecular mechanisms that underlie this association. We used a multi-stage design to identify and validate genes that are associated with smoking-related ccRCC. METHODS We first conducted a microarray study to com...

Introduction: The degree of polymerization depends on the type of light-curing unit. The aim of this study was to compare the hardness of composite resin cured by LED and Halogen light curing units. Methods: In this experimental study, 20 cylindrical samples of Tetric Ceram composite were prepared. Half of them were cured with Ultralume 2 LED and the other half with Astralis 7 Halogen light cur...

One important aspect of the relationship between spoken and written Chinese is the ranked syllable-tocharacter mapping spectrum, which is the ranked list of syllables by the number of characters that map to the syllable. Previously, this spectrum is analyzed for more than 400 syllables without distinguishing the four intonations. In the current study, the spectrum with 1280 toned syllables is a...

This study was conducted to assess the effect of hemodialysis (HD) on prolactin and testosterone level and their relations with study variables in chronic kidney disease (CKD) male patients. In a crosssectional study carried out in 80 males aged range from (22 to 80 years old), timed pre and post-HD samples were collected. Serum prolactin, testosterone, urea and creatinine were measured by usin...

All meconium aspiration syndrome cases admitted in the two neonatal units were compared to evaluate the antenatal and natal events including resuscitative measures and outcome of neonates and to confirm the beneficial effects of immediate combined obstetric and paediatric intervention on morbidity and mortality. Neonates managed in nursery at Mayo Hospital (Group 1, n = 44) were delivered at ot...

BACKGROUND Liver stiffness measurement (LSM) using Fibroscan is an increasingly popular non-invasive method for quantifying liver fibrosis in patients with chronic viral hepatitis. We aimed to explore potential impact of Fibroscan on clinical management. MATERIAL AND METHODS 133 patients with chronic hepatitis B (HBV, n = 75) or C (HCV, n = 58) underwent Fibroscan measurement. LSM results wer...

Gingival recession is characterized by the apical migration of the gingival margin, exposing the root surface. Studies have demonstrated several etiological factors for gingival recession such as periodontitis, traumatic toothbrushing, use of oral piercing, and past orthodontic therapy, among others. It might not be possible to identify and quantify the influence of each factor, and gingival re...