The mammalian genome encodes 49 proteins that possess a PX (phox-homology) domain, responsible for membrane attachment to organelles of the secretory and endocytic system via binding of phosphoinositide lipids. The PX domain proteins, most of which are classified as SNXs (sorting nexins), constitute an extremely diverse family of molecules that play varied roles in membrane trafficking, cell si...

ed actuation: Inflation by force in normal direction Actuation location: applied to membrane Actuation type: PZ (force in local z-direction) Support condition: 1 x Fixed support (YP = PX + PZ) 1 x Pinned support (PP = PX + PY + PZ)

Insulin deficiency affects the adult metabolic response to undernutrition, but its effects on the fetal response to maternal undernutrition remain unknown. This study examined the effects of maternal fasting for 48 h in late gestation on the metabolism of fetal sheep made insulin deficient by pancreatectomy (PX). The endocrine and metabolic responses to maternal fasting differed between intact,...

We have proposed that a hyperstimulated insulin secretion causing β-cell degranulation is the basis for the impaired glucose-potentiated insulin secretion in type 2 diabetes ("overworked β-cell"). To confirm this idea, we previously investigated tolbutamide-infused euglycemic rats. Two novel kinds of β-cell dysfunction were observed: altered phasic glucose-potentiated insulin secretion with pre...

The phosphatidylinositol-3-kinase (PI3K)/Akt oncogenic pathway is critical in glioblastomas. Loss of PTEN, a negative regulator of the PI3K pathway or activated PI3K/Akt pathway that drive increased proliferation, survival, neovascularization, glycolysis, and invasion is found in 70%-80% of malignant gliomas. Thus, PI3K is an attractive therapeutic target for malignant glioma. We report that a ...

It has been reported that selective serotonin reuptake inhibitors (SSRIs) possess some cardiac effects. In the present study we have investigated the effect of paroxetine (PX), a potent SSRI agent, on spontaneously as well as ouabain-induced arrhythmia beating isolated guinea-pig atria. The Guinea-pig heart was rapidly removed; the auricles were dissected out in oxygenated modified Krebs soluti...

PURPOSE Thioredoxin-1 (Trx-1) is a cellular redox protein that promotes tumor growth, inhibits apoptosis, and up-regulates hypoxia-inducible factor-1alpha and vascular endothelial growth factor. Objectives of this study were to determine safety, tolerability, pharmacodynamics, and pharmacokinetics of PX-12, a small-molecule inhibitor of Trx-1. EXPERIMENTAL DESIGN Thirty-eight patients with ad...

1 School of Mechanical Engineering, Kumoh National Institute of Technology, Kumi, Kyungbuk, South Korea 2 School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, Georgia, USA 3 Center for Assistive Technology and Environmental Access (CATEA), Georgia Institute of Technology, Atlanta, Georgia, USA # Corresponding Author / E-mail: [email protected]; Tel: +82-54-478-7344; Fax:...

Changes in emotions affect our physiological responses, and perhaps vice versa. We investigate a new game interaction system that uses false heart rate (fHR) feedback to improve the player experience (PX). The fHR presents HR information players so they perceive changes presented as being result of alteration PX. introduced auditory into investigated its effects through an experiment. Participa...