Objective: To determine the anti-tuberculosis drugs effect on lipid profile parameters in pulmonary tuberculosis (TB) patients.Methods: A prospective cross-sectional study was conducted at Tehsil Headquarter Hospital, Taunsa Sharif and District Teaching Dera Ghazi Khan from December 2020 to May 2021. The blood samples 84 positive TB patients were collected three different intervals of study, be...

Diagnosing child TB is a challenge in 22 High Burden Countries (HBCs) including Bangladesh. WHO estimates the case detection rate should be 6-10% of total TB cases. Recent publication shows it can be 4-22%, with sporadic reports form HBCs up to 25%. In Bangladesh, case detection was 3.1% in 2011, 2.85% in 2012 and it was 2.74% in 2013. Moreover, case detection rate in the sub-district hospitals...

BACKGROUND/PURPOSE This retrospective study was conducted to evaluate the drug resistance patterns of Mycobacterium tuberculosis in a medical center in northern Taiwan between 2003 and 2004 in comparison to those reported in 1990-1992. METHODS A total of 611 non-duplicate M. tuberculosis isolates from culture-proven tuberculosis (TB) cases were tested for drug susceptibility against five firs...

A novel method for the detection of any alteration within a defined sequence has recently been demonstrated (A. Lishanski, N. Kurn, and E. F. Ullman, Nucleic Acids Res. 28:E42, 2000; A. Lishanski, Clin. Chem. 46:9, 2000). Essential to this method are the generation of partial duplexes that are capable of forming four-stranded structures and the ability to detect inhibition of branch migration i...

Pyrazinamide (PZA) is an important first-line antituberculosis drug because of its sterilizing activity against semidormant tubercle bacilli. In spite of its very high in vivo activity, its in vitro activity is not apparent unless an acidic environment is available, which makes PZA susceptibility testing difficult by conventional methods. The present study was, therefore, planned to assess the ...

Background: Pyrazinamide (PZA) is among the first-line drugs to treat tuberculosis, and kills the semidormant mycobacteria only in a low-pH condition. And, the association between PZA resistance and pncA mutation has been studied. The purpose of this study was to compare PZA resistance to pyrazinamidase (PZase) activity and the genotype, to more understand the molecular basis of PZA resistance,...

BACKGROUND Antituberculosis (anti-TB) drug allergy often involves multiple concurrently administered drugs which subsequently need to be reinitiated as no better alternatives exist. OBJECTIVE To describe the results of tailored sequential desensitization-rechallenge (D-R) for anti-TB drug allergy. METHODS Consecutive patients who had undergone D-R to anti-TB drugs between 1 September 1997 a...

A 39-year-old immigrant from South-East Asia presented with several months of worsening upper back pain. He described night sweats and weight loss put denied any other complaints. On admission, computed tomography scan showed destruction of the 5th thoracic vertebral body with paraspinous soft tissue mass that narrowed the central canal (Figure 1, upper panel). Decompression surgery was done. S...

BACKGROUND & OBJECTIVES The emergence of drug resistance tuberculosis (TB) is a significant challenge for TB control and prevention programmes, and the major problem is multidrug resistant tuberculosis (MDR-TB). The present study was carried out to determine the frequency of drug resistant Mycobacterium tuberculosis isolates among newly and retreated TB lymphadenitis patients and risk factors f...