Escherichia coli KG980, a vitamin B6 auxotroph derived from E. coli K12, utilized the three unphosphorylated forms of vitamin B6, more or less effectively, for growth, but did not utilize the three phosphate forms at concentrations ranging from 10(-7) to 10(-5) M in the minimum medium of Davis and Mingioli. The bacterium, however, utilized the phosphate forms, although less effectively than the...

BACKGROUND Homocysteine, a risk factor of cardiovascular disease, cognitive disorders, and pregnancy complications, exists at a point of metabolic convergence of several B vitamins, including vitamins B(6) and B(2) (riboflavin). Measurement of the various forms of these vitamins may be useful for the study of hyperhomocysteinemia as well as for the assessment of vitamin status. METHODS Plasma...

The first naturally occurring form of vitamin B6 was isolated in 1938. It has the structure, confirmed by chemical synthesis (1939), of 3-hydroxy-4,5-bis(hydroxymethyl)-2-methylpyridine (I; R = -CHzOH). The trivial name “pyridoxine,” proposed for this compound by P. GyGrgy, came into general use as a synonym for “vitamin Be.” Two other natural compounds possessing vitamin B6 activity, detected ...

The first naturally occurring form of vitamin B6 was isolated in 1938. It has the structure, confirmed by chemical synthesis (1939), of 3-hydroxy-4,5-bis(hydroxymethyl)-2-methylpyridine (I; R = -CHzOH). The trivial name “pyridoxine,” proposed for this compound by P. GyGrgy, came into general use as a synonym for “vitamin Be.” Two other natural compounds possessing vitamin B6 activity, detected ...