the present study aims at indicating the existence and uniqueness result of system in extended colombeaualgebra. the caputo fractional derivative is used for solving the system of odes. in addition, rieszfractional derivative of colombeau generalized algebra is considered. the purpose of introducing rieszfractional derivative is regularizing it in colombeau sense. we also give a solution to a n...

Recent studies have considerably clarified the mechanism ofhydrolysis of ribonucleic acids (RNA) by pancreatic ribonuclease and by spleen phosphodiesterase. Digestion ofRNA with ribonuclease results in the splitting of all pyrimidine-pyrimidine internucleotidic links and of those pyrimidine-purine internucleotidic links which involve C(3w) of the pyrimidine nucleotide (Schmidt et al. 1951; Mark...

In this contribution several new coordination compounds on the basis of cadmium(II) thio- and selenocyanate with pyrimidine as co-ligand were prepared and investigated for their structural, thermal and spectroscopic properties. The reaction of cadmium(II) thiocyanate with pyrimidine leads to the formation of four compounds, which from a structural point of view are closely related. In the most ...

A straightforward and effective strategy for the synthesis of novel 7-cyano-4-imino-3-phenyl-6-(pyrrolidin-1-yl)-2-substituted-3,4-dihydroselenopheno[3,2-d]pyrimidines have been accomplished through a base-promoted cascade addition/cyclization sequence employing phenyl isothiocyanate followed by S-alkylation obtained fused Se-containing heterocyclic framework with various alkyl halides. Free ra...

Human cytomegalovirus (HCMV) induces numerous changes to the host metabolic network that are critical for high-titer viral replication. We find that HCMV infection substantially induces de novo pyrimidine biosynthetic flux. This activation is important for HCMV replication because inhibition of pyrimidine biosynthetic enzymes substantially decreases the production of infectious virus, which can...

In an endeavor to find a novel series of antihyperglycemic agents, new benzimidazole and pyrimidine derivatives were successfully synthesized efficiently in high yield with high purity, starting from amino acids in the presence of phosphorus oxychloride (POCl3). The synthesized compounds were identified by 1H-NMR, 13C-NMR, FT-IR spectroscopic techniques and elemental analysis. All products were...

The title compound, [Cu(C(5)H(3)N(2)O(2))(2)], was prepared in a water-ethanol solution containing 2-cyano-pyrimidine, malonic acid and copper(II) nitrate trihydrate. The Cu(II) ion, located on an inversion center, is chelated by two pyrimidine-2-carboxyl-ate anions in a CuO(2)N(2) square-planar geometry. The uncoordinated carboxyl-ate O atom and pyrimidine N atoms are linked to adjacent pyrimi...

Purine and pyrimidine nucleotides play critical roles in DNA and RNA synthesis as well as in membrane lipid biosynthesis and protein glycosylation. They are necessary for the development and survival of mature T lymphocytes. Activation of T lymphocytes is associated with an increase of purine and pyrimidine pools. However, the question of how purine vs pyrimidine nucleotides regulate proliferat...

Non-covalent and site-directed spin labeling gives easy access to spin-labeled nucleic acids for the study of their structure and dynamics by electron paramagnetic resonance (EPR) spectroscopy. In a search for improved spin labels for non-covalent binding to abasic sites in duplex DNA and RNA, ten pyrimidine-derived spin labels were prepared in good yields and their binding was evaluated by con...