The fungal pathogen Candida albicans causes lethal systemic infections in humans. To better define how pathogens resist oxidative attack by the immune system, we examined a family of four Flavodoxin-Like Proteins (FLPs) in C. albicans. In agreement with previous studies showing that FLPs in bacteria and plants act as NAD(P)H quinone oxidoreductases, a C. albicans quadruple mutant lacking all fo...

Objectives: The aim of this study was to compare standard triple therapy regimen with sequential therapy regimen containing levofloxacin used for the eradication of H. pylori in patients with gastrointestinal infection caused by H. pylori. Methods: This single blind clinical trial study was conducted on 96 patients with positive Rapid Urease Test (RUT) who were referred to the Endoscopy center ...

Adrenocortical cancer is an orphan tumor with poor prognosis. The combination of EDP chemotherapy regimen and mitotane the standard for first‑line therapy. But there are no effective options second consequent lines second‑line therapy gemcitabine, capecitabine mitotane, which provides objective response in 4–7 % patients. Achievement therapeutic concentration most important predictive factor ef...

OBJECTIVES Incidence and risk factors of post-transplant monoclonal gammopathy were studied in renal transplant patients who received their grafts between 1982 and 1992 (n = 390 grafts). Immunoelectrophoresis was performed at annual intervals after transplantation. RESULTS Forty-six cases of clonal gammopathy were detected: 35 monoclonal, 11 bi- or triclonal, with a predominance of IgG and ka...

Background: The ideal combination regimen for Helicobacter pylori (HP) eradication has not yet been determined and the success rate of HP extensively reduced worldwide due to increasing antibiotic resistance. So this multinational multi-center randomized controlled trial was designed evaluate efficacy tetracycline +levofloxacin eradication. Methods: During a 6-month period, all cases with infec...

BACKGROUND/AIMS Helicobacter pylori eradication rates with standard triple regimens are worsening, and alternative treatments are urgently needed in some populations. The present study aimed to compare the efficacy of bismuth-based quadruple and concomitant regimens. METHODS Consecutive Helicobacter pylori-positive patients with non-ulcer dyspepsia were randomized to receive one of two regime...

Approximately 30% to 40% of women with gestational diabetes (GDM) receive insulin therapy, and the multiple daily injection (MDI) regimen a combination basal prandial is generally used, as in cases prepregnancy diabetes. We developed simple (SII) regimen, which one or two injected doses are for mild GDM who require therapy. The present study explored whether not SII effective MDI preventing fet...