In this paper we report the design, synthesis and pharmacological evaluation of a new series of phenyl sulfonamide derivatives 2a-h and 3-8 planned by structural modification on the anti-inflammatory prototype LASSBio-468 (1). Among the synthesized analogues, the tetrafluorophthalimide LASSBio-1439 (2e) stands out showing an in vitro anti-TNF-α effect similar to the standard thalidomide. The re...

Abscisic acid (ABA) is easily isomerized to inactive trans-ABA by light. To solve this problem, two variations of epoxy-ᵚ-ionylideneacetic acid were synthesized as ABA analogs, each of them having a methoxycarbonyl or a fluoric substituent at the 2-position. The 2E-, and 2Z-fluorinated analogs showed moderate growth inhibitory activity toward rice seedlings and lettuce seeds, whereas the methox...

For a graphG, let P(G) be its chromatic polynomial. Two graphsG andH are chromatically equivalent if P(G)=P(H). A graph G is chromatically unique if P(H)= P(G) implies that H G. In this paper, we classify the chromatic classes of graphs obtained from K2,2,2 ∪ Pm(m 3), (K2,2,2 − e) ∪ Pm(m 5) and (K2,2,2 − 2e) ∪ Pm(m 6) by identifying the end-vertices of the path Pm with any two vertices of K2,2,...

Electron-electron coincidence experiments have experienced over the past twenty years an increasingly rapid expansion and application to many different fields. Among them, the (e,2e) spectroscopy has been successfully used to investigate either the target electronic structure or the ionisation dynamics. The capability of this spectroscopy to investigate single particle properties in atoms, mole...

ASTRONOMY AND ASTROPHYSICS ROSAT archival observations of 1SAX J0054.9–7226 = 2E 0053.2–7242, a newly discovered X–ray pulsar in the SMC Abstract. We analysed 13 archival ROSAT PSPC and HRI observations which included the position of a newly discovered 59 s X–ray pulsar in the Small Magellanic Cloud, 1SAX J0054.9–7226 = 2E 0053.2–7242. The source was detected three times between 1991 and 1996 a...

The Youla parameterization (also the Q – parametrization) is a modern control design method suitable for both stable and unstable plants. In the design phase systems with electrical drives can be well approximated through low order linear models called benchmarks. For such system it can be advantageous to use control design based on modulus optimum criterion (Modulus Optimum MO-m and Symmetrica...

In the two-echelon vehicle routing problem (2E-VRP), distribution network is split into two echelons. Different vehicles are operated on first and second echelon to maintain economies of scale adhere any restrictions that may be present in either echelon. Intermediate facilities located at borders echelons facilitate consolidation transshipment goods between Examples systems include express del...