Two-phase single-case designs, including baseline evaluation followed by an intervention, represent the most clinically straightforward option for combining professional practice and research. However, unless they are part of a multiple-baseline schedule, such designs do not allow demonstrating a causal relation between the intervention and the behavior. Although the statistical options reviewe...

quantitative relationships between molecular structure of forty eight aldehyde compounds with their known cathepsin k inhibitory effects were discovered by partial least squares (pls) method. evaluation of a test set of 10 compounds with the developed pls model revealed that this model is reliable with a good predictability. since the qsar study was performed on the basis of theoretical descrip...

In the theoretical section of the present paper, we develop our view of the roles played by the perceptual criteria: indistinguishably equal, neither blue nor yellow, neither green nor red, and heterochromatically equally bright. These criteria constitute a vectorial opponent-colour space, a concept used throughout the paper. Within this framework, two new theorems on psychophysical opponent-co...

The alkaline phosphatase (ALP) assay is a rapid and convenient method for verifying milk pasteurization. Since colorimetric ALP assays rely on subjective visual assessments, their results are especially unreliable near the detection limits. In this study, we attempted to establish quantitative criteria for residual ALP in milk by using a more objective method based on spectrophotometric measure...

Identity and access management (IAM) systems are used to assure authorized access to services in distributed environments. The architecture of IAM systems, in particular the arrangement of the involved components, has significant impact on performance and scalability of the overall system. Furthermore, factors like robustness and even privacy that are not related to performance have to be consi...

A robust state feedback design subject to placement of the closed loop eigenvalues in a prescribed region of unit circle is presented. Quantitative measures of robustness and disturbance rejection are investigated. A stochastic optimization algorithm is used to effect trade-off between the free design parameters and to accomplish all the design criteria. A numerical example is given to illustra...

Introduction The diagnosis of hypochondroplasia (HCH) is hampered by absence of radiological criteria relevant to the agedependent manifestations, particularly those in the neonatal period. This work deals with the radiological features in hypochondroplastic neonates with a FGFR3 mutation, including quantitative measurement that facilitates the definitive diagnosis. We propose the radiological ...

This paper proposes acceptance criteria for quantitative comparison metrics to be applied in the Verification and Validation (V&V) process of computational models used in roadside safety. Typically, the degree of verification or validation of a numerical model is assessed by qualitatively comparing the shapes of two curves, but qualitative comparisons are subjective and open to interpretation. ...

The decision criteria for the physical appearance of pharmaceutical products are subjective and qualitative means of evaluation that are based entirely on human interpretation. In this study, we have developed a comprehensive method for the quantitative analysis of the physical appearance of film coated tablets. Three different kinds of film coated tablets with considerable differences in their...

In the last few years, there has been an increasing growth in the number of collaborative partnerships between suppliers and manufacturers as a means to meet more complex customer needs and remain competitive. Selecting suppliers for a collaborative new product development (CNPD) process is a multicriteria decision making problem involving both qualitative and quantitative factors. The aim of t...