Sera of 12 patients with quinine/quinidine-induced thrombocytopenia showed drug-dependent antibody binding to glycoprotein (GP) Ib-IX complex. The reaction with GPIb-IX complex of 11 of these 12 sera was strongly inhibited by the complex-specific monoclonal antibodies (MoAbs) AK1 and SZ1. The exception was a quinine-induced serum designated BU. The reaction of the six quinidine-induced sera was...

We report a patient with diabetes mellitus who suffered severe falciparum malaria complicated by profound and persistent hypoglycaemia. The hypoglycaemia evolved before therapy with quinine was begun and resolved with eradication of the parasitaemia. The patient reverted to her baseline hyperglycaemia despite continuation of quinine. This case illustrates the critical role of falciparum malaria...

Sir,?In reply to this question, l-ecently asked in the 7. M. G., I have to state that I have given quinine, both by the mouth, hypodermic and intramuscular injections, for malaria in pregnant patients without any harmful result. The following case, however, is both interesting and peculiar. An unmarried lady could not take more than five grains of quinine on a sea voyage without producing a flo...

ALTHOUGH amaurosis due to quinine poisoning is now relatively rare, occasional cases still occur. When quinine is used as an abortifacient, the initial history may be misleading, as in the present case, but the presence of characteristic changes in the fundi usually enables one to be reasonably certain in arriving at a diagnosis. The present case is considered worthy of special record in view o...

is so strenuous that we may soon expect to see the subject filmed, and the sadistic character of the exponents of this method of treatment shown up by lime-light. I am surprised that hitherto no one has had the temerity to break a lance on the subject, and I can only conclude the reason to be that the practice of intramuscular injections appears to be almost universal in malarial countries, but...

background: malaria remains the world’s most devastating human parasitic infection. our goal was to assess the capacity of increasing concentrations of five antimalarial drugs (fansidartm, halfantm, quinine, coartemtm and chloroquine phosphate) to elicit the generation of methemoglobin in three human erythrocyte genotypes (hb aa, hb as and hb ss). materials and methods: spectrophotometric metho...

A new hypothesis is presented here to explain recent observations about drug-induced immune thrombocytopenia (DIT).1 Characterization of quinine-dependent autoantibodies has led to the current paradigm that quinine associates noncovalently with a target platelet receptor and induces formation of a neo-epitope that can elicit specific immune response. It was thought that quinine binds to a favor...

The pharmacokinetics of increasing doses of an intrarectal Cinchona alkaloid combination containing 96.1% quinine, 2.5% quinidine, 0.68% cinchonine, and 0.67% cinchonidine (Quinimax) was compared to that of parenteral regimens in 60 children with moderate malaria. Quinine exhibited a nonlinear pharmacokinetics, suggesting a saturation of rectal resorption. When early rejections appeared, blood ...

From March 1996 to August 1997, a study was carried out in a malaria endemic area of the Brazilian Amazon region. In vivo sensitivity evaluation to antimalarial drugs was performed in 129 patients. Blood samples (0.5 ml) were drawn from each patient and cryopreserved to proceed to in vitro studies. In vitro sensitivity evaluation performed using a radioisotope method was carried out with the cr...