The multicomponent reaction of aldehydes, amines, and alkynes, known as A3 coupling, yields propargylamines, a valuable organic scaffold, has received significant interest attention in the last years. In order to fully realise potential metal-based catalytic protocols that facilitate this transformation, we summarise substrates, situ well-characterised synthetic methods provide scaffold attempt...

We have recently reported a novel multicomponent reaction between arylacetic acids and isocyanides, affording α-acyloxyacrylamides through an unusual mechanism. The products of this novel multicomponent reaction can rearrange to five membered heterocyclic compounds when exposed to an alkaline environment. Depending on the reaction conditions and on the substitution pattern on the substrates, va...

Various investigators have reported on methods for the estimation of iodine in air, food, water, vegetables, tissue, and blood. Chatin (1) in 1851 used the method of Rabourdin (2) and established the presence of iodine in air. Rabourdin’s method depends on converting the iodine to potassium iodide, setting it free with nitrous acid, and extracting with carbon disulfide. Detection was possible i...

A Pd/C/Zn mixture with alcohols has been revealed to be an efficient transfer hydrogenation system to quinolines. Furthermore, the metals mixture is able to activate alcohols as N-alkylating agents in a hydrogen autotransfer process. 1,2,3,4-Tetrahydroquinolines and N-alkylated tetrahydroquinolines from quinolines have been obtained with excellent yields in one step.

A variety of diallylanilines are shown to undergo cobalt-carbonyl catalyzed rearrangement to quinolines. Diallylanilines are also used as allyl transfer reagents to convert benzaldimines into quinolines. Substitution in the 2- and 3-positions of the quinoline is featured in all transformations.

Abstract An efficient and straightforward approach has been established for the preparation of a new class depsipeptide structures via isocyanide-based consecutive Bargellini–Passerini multicomponent reactions. 3-Carboxamido-isobutyric acids bearing an amide bond were obtained Bargellini reaction from isocyanides, acetone, chloroform in presence sodium hydroxide. Next, Passerini multicomponent-...

In this study a multicomponent reaction involving carbohydrate derivatives as the main component in order to prepare a new library of polyhydroxy compounds incorporating pyrimidine-fused heterocycles (PFHs) is introduced. A set of polyhydroxy functionalized PFHs were synthesized using multicomponent reactions of sugar (glucose, galactose, arabinose and lactose), barbituric acid and amines. Also...

Bunsen reaction was performed electrochemically using cation exchange membranes prepared by a radiation-induced grafting method for application to the iodine-sulfur thermochemical water-splitting cycle. The reaction experiments using sulfuric acid dissolving sulfur dioxide as the anolyte and hydriodic acid dissolving iodine as the catholyte verified the progress of the aimed reaction. Compared ...

a series of 2-amino pyridine-3-carbinitrile derivatives incorporated coumarin moiety has developed via multicomponent condensation of 3-acetyl-2h-chromen-2-one, arylaldehydes, malononitrile and ammonium acetate utilizing brønsted acidic ionic liquid, (4-sulfobutyl)tris(4-sulfophenyl)phosphonium hydrogen sulfate as catalyst under solvent-free conditions. good yields, short reaction times, straig...

A facile and one-pot multicomponent synthesis of novel 1,4-disubstituted-1H-1,2,3-triazoles from alkenes at room temperature is reported. At the first step, in the presence of I2/NaN3 reagents, various alkenes were converted to the corresponding azido iodides and in the next step, the reaction of these compounds with phenylacetylene in the presence of catalytic amount of sodium ascorbate/ CuSO4...